Doctor in identifying DNA damage using single molecule imaging

The Westerlund group is looking for a motivated candidate to work on our assay of using single DNA molecule imaging for quantifying DNA damage caused by DNA damaging drugs. The goal is an assay that can identify patients sensitive to certain chemotherapuetic drugs. We are also interested in identifying the mechanism of action for novel DNA-damaging drugs. The project is a close collaboration with clinicians at Sahlgrenska University Hospital and synthetic chemists at Dublin City University.

Information about the division/the project
The Chemical Biology division is the home of seven research groups. We combine and develop protein engineering, synthetic chemistry and state-of-the-art biophysical methos (spectroscopy, live-cell imaging and nanotechnology) to address cutting edge questions in biology to meet medical challenges related to human health. Our joint expertise is strategic and spans from molecular biophysics of single molecules to cell and organism biology.

Job description
The Westerlund group uses fluorescence microscopy to image single molecules with a strong focus on DNA. The research ranges from basic science of DNA-protein interactions to clinical and diagnostic applications, in particular for infectious diseases and cancer. One theme of the group is to analyse DNA damage in order to identify patients that are sensitive to certain chemotherapeutic drugs.

Major responsibilities
The person hired will work on all aspects of the experiments including handling cells, inducing damage, extracting DNA, labeling DNA, image DNA and analyse data. The person will present research orally and in scientific publications.

Qualifications
The person should have experience in handling cells, molecular biology tools, fluorescence microscopy and data analysis. Extensive experience in presenting research orally and in written form is important.

Contract terms
Temporary full-time employment (One year duration).

We offer
Chalmers offers a cultivating and inspiring working environment in the coastal city of Gothenburg .
Read more about working at Chalmers  and our benefits  for employees.

Chalmers aims to actively improve our gender balance. We work broadly with equality projects, for example the GENIE Initiative on gender equality for excellence . Equality and diversity are substantial foundations in all activities at Chalmers.

Application procedure
The application should be marked with Name, 20240016  and be attached as PDF files, as below:

CV

Personal letter

Other documents (optional):
• Copies of completed education, grades etc. Two references that we can contact should be provided at a possible interview.

Please use the button at the bottom of the page to reach the application form.

Application deadline: 2024-02-09

For questions, please contact:
Prof. Fredrik Westerlund, Div. Chemical Biology,
[email protected], 0317723049

*** Chalmers declines to consider all offers of further announcement publishing or other types of support for the recruiting process in connection with this position. ***

Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our six Areas of Advance; Energy, Health Engineering, Information and Communication Technology, Materials Science, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!

URL to this page
https://www.chalmers.se/en/about-chalmers/work-with-us/vacancies/?rmpage=job&rmjob=12505&rmlang=UK