The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with other research groups from the Karolinska Institutet, with other universities as well as the Stockholm County Council.
Please visit our website for more information: ki.se/en/cns
Alpha Synuclein is an abundant, presynaptically localized protein which accumulation in the form of misfolded oligomers and large aggregates is strongly linked to pathology of Parkinson’s disease and other neurodegenerative disorders. However, the cellular role of alpha Synuclein has remained largely unclear. Our laboratory is interested to further elucidate the physiological function of alpha Synuclein and a special focus will be on alpha Synuclein-dependent modulation of presynaptic release machinery, including modulation of synaptic vesicle pools and underlying signaling pathways. Understanding the physiological function of alpha Synuclein in neuronal transmission will open new avenues for development of novel therapeutic strategies. Thanks to the breadth of methodological approaches our laboratory is capable of translating results from molecular and cellular assays into the preclinical stage.
The successful candidate will be preferentially responsible to run primary neuronal culture as a model system to study the effect of alpha Synuclein on presynaptic structure and function employing wide spectrum of molecular and cell biology technics and live cell imaging. The applicant will also develop in vitro assay methods for biological characterization of animal models of Parkinsonism, targeting components involved in synaptic transmission. He/she will be encouraged to serve as mentors for PhD, bachelor and master students over the year. The applicant should show independency in his/her work but also to be a strong team player and motivated to work in a vibrant international and multidisciplinary research group. Establishment of national and international collaborations is highly encouraged.
Applicant should have completed a PhD in neuroscience and at least five years of postdoc experience within the field of Neuropharmacology, preferably with a broad working knowledge on physiology of synaptic transmission and the associated investigative tools and methods. Hands on experience with the preparation and cultivation of primary neuronal cells and live cell fluorescence imaging is a prerequisite for this position. In addition, candidate must demonstrate extensive experience with methods of molecular and cellular neuroscience, cellular pharmacology, biochemistry and keen interest in quantitative approaches. A comprehensive understanding of neurodegenerative disease biology and PD animal models is an advantage. The successful applicant should have proven record in planning, implementing, managing and developing research projects as well as an experience in attracting and supervising students. Therefore, excellent communication skills and fluency in English language are highly preferred.
A person is eligible to be appointed Assistant professor if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence.
Bases of assessment
We stress scientific expertise when assessing applicants.
An application must contain the following documents in English or Swedish: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio ).
The application is to be submitted through the MyNetwork recruitment system.
An Assistant professor position is a fixed-term position. The first employment should be two years, with a possible extension of two years after evaluation.
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