Assistant Professor in Genomics of adaptation to climate change

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

The SciLifeLab Drug Discovery & Development platform (SciLifeLab DDD, www.scilifelab.se/units/ddd-platform/) comprises several units with unique competencies related to biologics and small molecule drug discovery and development. Typically, our drug development projects stem from academic basic science in which opportunities to intervene with disease processes with biologics, oligonucleotides, or small molecules have been identified and perceived to have commercial potential.

The Human Antibody Therapeutics (HAT) consists of six senior researchers, scientifically supported by three platform scientific directors (professor level). The unit’s primary responsibility is to drive the DDD antibody drug discovery programs and to deliver tailor-made antibody candidates with a proven translational effect. The in-house developed phage-display human antibody libraries are an essential component of this work. The projects are progressed in close collaboration with primarily the Protein Expression and Characterization unit and the other competencies in the SciLifeLab DDD infrastructure (approx. 45 employees) as well as with academic principal investigators (PIs). The team is also responsible for additional in vitro selection-based methods, such as DNA-encoded chemical libraries for discovering small molecule drug candidates.

The Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH School) at KTH, is now looking to recruit a researcher to the Human Antibody Therapeutics (HAT) unit at SciLifeLab DDD in Stockholm.

The job includes the following main tasks:

• lead antibody projects within the platform which includes:
• to lead a project group consisting of members from the platform and external collaborators
• to be responsible for planning, execution and follow up of activities
• effective and transparent communication of plans and results within and outside the platform
• contribute in the lab by performing activities such as in vitro selection and binding and biophysical characterization of selected candidates
• identify and evaluate optimization of antibody candidates to improve functional and biophysical characteristics
• explore and evaluate novel disease modifying mechanisms based on protein protein interactions

The position offers excellent opportunities for innovation and development since our ambition is to deliver antibody candidates that is at par with industry standards.

• A position at an internationally leading and highly cross-disciplinary infrastructure with a proven track record of delivering pharmaceutical candidates from academic research ideas.
• Engaged, ambitious colleagues and a creative, international, and dynamic working environment.
• Work in Stockholm, in close proximity to nature.
• Help to relocate and be settled in Sweden and at KTH
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• PhD in biotechnology, cell or molecular biology, biochemistry, biophysics, or immunology.
• Proven track record of independent work demonstrating skills in molecular biology, protein expression, purification and characterization
• Demonstrated experience from phages display technology
• Demonstrated experience from protein engineering
• Excellent ability to communicate in English, both orally and in writing.

• Experience in project leadership
• Experience in alternative in vitro display techniques
• Experience in protein expression using different systems
• Experience from the pharma/biotech industry

Great emphasis will be placed on personal competency, and in addition to the mentioned qualifications above, a successful candidate is also expected to meet the following requirements:

Great emphasis will be placed on personal competency, and in addition to the mentioned qualifications above, a successful candidate is also expected to meet the following requirements:

• Excellent teamwork ability and a goal and results-oriented focus.
• A high ability to adopt new methods and ways of working
• Excellent problem-solving analytical ability with an independent, structured, and thorough working style
• A high degree of integrity, motivation, and flexibility at work