VAC_06_2024_POSTDOCTORAL BIOINFORMATICS_Regulation Of Blood Stem Cell Identity

18 Jan 2024
Job Information

Organisation/Company

Josep Carreras Leukaemia Research Institute (IJC)

Research Field

Medical sciences » Cancer research

Researcher Profile

Recognised Researcher (R2)

Country

Spain

Application Deadline

15 Feb 2024 - 12:00 (Europe/Madrid)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

39

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Josep Carreras Leukemia Research Institute (IJC) is a nonprofit research institute based in Barcelona and dedicated to advancing our understanding about leukemia and related disorders, in partnership with the University of Barcelona and the University Autònoma of Barcelona. The IJC has laboratories in 4 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau iii) Hospital Germans Trías, and iv) Pujol and Hospital del Mar. IJC serves as a collaborative hub for basic investigators and physicians to work together on fundamental biological and clinical aspects of leukemia. The IJC offers an excellent work environment built around a multi-disciplinary fusion of ideas and state-of-the-art facilities. 

Research Description 

The Josep Carreras Research Institute is looking for a POSTDOCTORAL BIOINFORMATICS   who supports the Regulation Of Blood Stem Cell Identity group, led by Dr. Vincenzo Calvanese.

Hematopoietic stem cells (HSC) are a life-saving therapy for leukaemia and have found broadened applications to gene and cell therapy, against other cancers, genetic, autoimmune, and infectious diseases. Yet, practical limitations, such as donor-matching or insufficient cell number render these therapies unfeasible or unsuccessful for many patients. Attempts to overcome these limitations have been unable to create a reliable source of HSC for patients: while we can generate human HSC from pluripotent stem cells, they resemble early development stages, lacking many of the functional maturation hallmarks. The Bioinformatic technician will join a team to work on several projects identifying core pathways for HSC generation, functional maturation, and maintenance and to define the contribution of coordinated gene expression by chromatin regulation to HSC identity. A combination of standard analysis pipelines and the generation of innovative analysis tools will be required. A significant volume of NGS data will require a skilled bioinformatics expert for dataset organization, high-level analysis, and data deposition.  This work will provide important advances in our understanding of human HSC development and in generating and maintaining HSCs in vitro, further enabling their full therapeutic potential.

What we need

• PhD in Bioinformatics, informatics applied to Life Sciences or similar. 
• Experience in bulk and single-cell NGS analysis, including genomics, transcriptomics, multiomics, and molecular barcoding technologies.
• Deep knowledge of R, Python, and bash programming
• Proficiency in Unix/Linux environments  
• Experience with software version control or HPC environments (SLURM) 
• Experience with advanced statistics/machine learning/computational modeling is highly desirable.
• Strong motivation and excellent organizational skills 
• Ability to work in tight collaboration with the other group members and to provide support and training in data analysis-related aspects. 
• Good level of spoken and written English. 

Responsibilities 

• Processing and analysis of the above detailed NGS data, coordinating with the group leader and other researchers for optimal extraction of the biological information.
• Design and improvement of pipelines and applications for data analysis.
• Management and curation of data and code repositories for easy accessibility to the scientific community. 
• Generation and maintenance of web interfaces for data browsing for non-experts.
• Data presentation and support to final generation of data visualization products.
• Independent thinking, enthusiasm, pro-activity, impeccable work ethics and professionalism.
• Commitment to an equity, diversity, and inclusion-based, international working environment, internal and external collaborations, and student supervision.

Requirements

Research Field

Medical sciences » Cancer research

Education Level

PhD or equivalent

Languages

ENGLISH

Level

Excellent

Research Field

Medical sciences » Cancer research

Years of Research Experience

1 - 4

Additional Information
Benefits

• A 3-year full-time contract. Possible long-term renewal 
• A competitive salary to be defined depending on candidate experience.
• The opportunity to contribute to a cutting-edge research project in the stimulating environment of the Josep Carreras Leukaemia Research Institute.
• The vibrant scientific and cultural environment of the Barcelona metropolitan area.
• Career Development Plan.

Work Location(s)

Number of offers available

1

Company/Institute

IJC Can Ruti

Country

Spain

State/Province

Barcelona

City

Badalona

Geofield

Where to apply

Website

https://institut-josep-carreras-ijc.jobs.personio.com/job/1384108?_pc=1242413#a…

Contact

State/Province

BARCELONA

City

Badalona

Website

http://www.carrerasresearch.org/en

Street

Ctra de Can Ruti, Camí de les Escoles s/n

Postal Code

08916

STATUS: EXPIRED