Single Cell Genomics – Laboratory Manager

The Institute

The Centro Nacional de Análisis Genómico (CNAG-CRG) is one of the largest Genome Sequencing Centers in Europe. CNAG-CRG researchers participate in major International Genomic Initiatives such as the International Cancer Genome Consortium (ICGC), the International Human Epigenome Consortium (IHEC), the International Rare Diseases Research Consortium (IRDiRC) and the European Infrastructure for life-science information (ELIXIR), as well as in several EU-funded projects.

It is integrated with the Centre for Genomic Regulation (CRG), an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

The candidate will be integrated in the Single Cell Genomics Team, a highly collaborative, international work environment with well-experienced colleagues in single-cell data production and analysis. The selected candidate will be responsible for the development and implementation of novel single-cell and spatial sequencing applications. Further responsibilities are the scouting of emerging methods related to key research areas of the team. The candidate will be leading the laboratory team and coordinate large-scale single-cell and spatial sequencing projects, including clinical trials. The candidate will also be responsible for the coordination of collaborative efforts of the Single Cell Genomics Team with our research and clinical partners and diverse production efforts of healthy and diseased human/mouse tissues.

The position will involve the coordination of the experimental part of several consortia funded by international and national agencies (e.g. ERC, H2020, LaCaixa, Chan-Zuckerberg Initiative projects). The projects the candidate will be involved in aim to understand the composition of healthy organs and tissues (Human Cell Atlas) and the molecular/cellular basis of immuno-therapy action by applying multi-omics single-cell and spatial characterisation of healthy and tumor microenvironment immune cells. The latter are obtained from clinical trials of immuno-therapy or advanced mouse model systems.

We are looking for a highly motivated and creative thinking individual who is interested in working in an environment where the technical sophistication of single-cell analysis meets innovative approaches for interpreting data and generating new knowledge. We encourage and prioritize applications from under-represented minority groups.    

About the team

The Single Cell Genomics Team at the CNAG-CRG is dedicated to advance genome research of single cells. The mission of the group is the implementation of single-cell sequencing technologies and their application in a research and translational context. The group focuses on the systematic integration of transcriptional and epigenetic data from individual cells to elucidate causalities underlying phenotype formation. We successfully established sequencing protocols to quantify gene expression and open chromatin of thousands of single cells. Our newly developed computational pipelines include methods to deconvolute tissue composition and track to transcriptional dynamics. Our international team joins computational, technical and biological knowledge in order to establish and apply best practices in single-cell research. The group combines collaborative research, development activities and follows research lines on the generation of human cell atlases and on translational cancer research. We are member of the Human Cell Atlas Project.

Web: http://www.cnag.cat/teams/genome-research-unit/single-cell-genomics-team

Whom would we like to hire?

Professional experience

Must Have

• You have demonstrated research excellence through peer-reviewed publications
• You have more than 10 year of work experience
• You have strong expertise in single-cell and spatial genomics techniques
• You have knowledge in genomics and experience with NGS library production
• You have excellent skills in molecular and cell biology techniques

Education and training

• You hold a PhD in molecular biology or similar

Languages

• You are proficient in English

Technical skills

• You have technical experience of experimental designs for research and clinical projects
• You have experience with technology scouting, development and implementation
• You have experience with process optimization for single-cell and spatial production processes
• You have experience in project coordination from sample processing to sequencing
• You have experince overseeing large-scale data generation efforts

Competences

• You have excellent communication and writing skills
• You have problem solving skills
• You have time managment and strategic thinking
• You are commitment to high-quality work
• You have sound administrative abilities
• You have lead and guidance of a laboratory team experience
• You have experience supervising the technical laboratory staff
• You have practice in training and supervision of researchers and technical staff
• You have experience in planning and coordinating of projects
• You have experience coordinating collaborative projects

The Offer

• Contract duration: Technical and scientific activities contract linked to the unit activities
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: July, 2022

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

1. A motivation letter addressed to Dr Holger Heyn.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Holger Heyn and be submitted online on the CRG Career site - http://www.crg.eu/en/content/careers/job-opportunities

Deadline: Please submit your application by July 6th, 2022.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.