Research Technician

The Institute 

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies. 

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).  

Please, check out our Recruitment Policy  

The role  

We are looking for an enthusiastic technician to join the Single Cell Epigenomics and Cancer Development team to provide support in creating a better understanding of early tumor formation. The candidate will be in charge of the development and implementation of novel protocols for manipulation of mammalian cell-culture based systems - potentially extended with in vivo studies – and to study the potential effects of given manipulations. The candidate will work in close collaboration with other lab members (a lab manager, PhD students and a postdoc) as well as in an independent manner. We are open to receive applications from both junior and senior candidates, as long as they meet the work experience requirements. 

About the lab 

Tumors originate from normal cells that acquire tumor-initiating genetic events, such as translocations and somatic mutations. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumor formation. For that, secondary genetic events as well as epigenetic hits are required.  

We are an expanding lab that recently was awarded an ERC starting grant providing funds for the coming 5 years. We aim to create a better understanding of how epigenetic tumor-associated changes arise in the context of non-Hodgkin lymphomas. To that end, we aim to study the occurrence of these changes in healthy individuals as well as in pre-malignant cells in vitro (to be created by CRISPR/Cas9 genomic editing) and in vivo using single-cell technologies. On top of that, we aim to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions, that influence the occurrence of the observed changes.  

We are affiliated to the Gene Regulation, Stem Cell and Cancer Research program of the CRG in double affiliation with the Centre for Genomic Analysis (CNAG-CRG) and the department of Oncology and Haematology of the IDIBAPS. We strongly believe that bringing the knowledge and resources of these different environments together majorly aids to better understand the biology of disease. Further information can be found at: https://www.crg.eu/en/programmes-groups/beekman-lab .