The project involves the use of the human gastruloid system (a human embryonic stem cell model of early human development; see PMID: 32528178) developed in the host lab, to create an in vitro mimic of the hematopoietic stem cell niche. The project is a collaboration with three other groups in Barcelona.
The tasks and responsibilities of the post will be the following:
1. Culture and growth of human Embryonic and induced Pluripotent stem cell lines.
2. Maintenance of a stem cell line bank
3. The development of the current gastruloid system towards the hematopoetic fate
4. Characterization of the gastruloids in terms of their gene expression and protein patterns.
5. Generation of new cell lines through genetic engineering.
6. Collaborate with and assist postdoctoral research associates in the work related to the project.
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