POSTDOCTORAL RESEARCH - 3D CHROMATIN ORGANIZATION

Research Description

We are currently seeking for an enthusiastic Postdoctoral Researcher to join the multidisciplinary project “Exhibit B - Engineering human B cells using synthetic biology and tissue engineering”. This project is funded by Wellcome Leap (https://wellcomeleap.org/hope/ ) and engage four teams: Javierre Team (IJC), Roser Vento-Tormo Team (Wellcome Sanger Institute), Leonardo Morsut Team (University of Southern California) and Kyung-Ho RohTeam  (The University of Alabama in Huntsville).

We are a group of passionate scientists with an insatiable thirst for learning about spatio-temporal organization of the DNA. Our group combines cutting-edge experimental and bioinformatics approaches to understand the specific 3D chromatin organization of haematopoietic cells and its alteration in blood cancers. Our long-term goal is to keep taking steps forwards in the fight against cancer.  We will be unstoppable until we cure it. To do so, we have established a close collaboration with the group lead by Alfonso Valencia, Barcelona Supercomputing Center (https://www.bsc.es/ ).

This contract is funded by the project Welcome Leap (Hope Program): Exhibit B - Engineering human B cells using synthetic biology and tissue engineering HOPE-2021-2754490174.

The main research goals of our lab are:

o   Defining the cell type-specific 3D chromatin organization in human haematopoietic cells.

o   Identifying the altered DNA topology in blood cancer

o   Study non-coding mutations to prioritize new candidate genes and pathways related to blood cancer based

For more information, please contract 3D Chromatin Organization Research Group's webpage (https://www.javierrelab.com/ ) and the IJC web page (https://www.carrerasresearch.org/en/3d-chromatin-organization_78766 ).

What we need

• A high level of motivation and interest.
• PhD degree in molecular biology, genomics, epigenomics, immunology or similar.
• Expertise, at least, on one of the following areas: B cells, genome organization, gene regulation, epigenetics and single cell omics. We encourage the applications of experimentalist and computational researches.
• Ability to handle varying workloads and aptitude for teamwork.
• High level of collaborative and communicative skills.
• Capacity for analysis and supervision.
• Good level of English speaking and writing skills (required). Spanish (helpful).

What we offer

• Two years and a half full-funded position. Salary will be adjusted according to the experience of the candidate.
• An exciting and innovative research project funded by the Human Organs, Physiology, and Engineering (HOPE) programme of the Wellcome Leap (https://wellcomeleap.org/ ).
• Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
• Incorporation in a multinational and highly collaborative team.
• The stimulating environment of the Barcelona metropolitan area.
• We will provide support and training to prepare competitive fellowship applications (e.g., Marie Curie, EMBO, FEBS, HFSP among others)

Main Responsibilities

• She/he will be part of the multidisciplinary research team of the project “Exhibit B - Engineering human B cells using synthetic biology and tissue engineering” led by Biola M. Javierre.
• Specifically, she/he will contribute to the generation or analysis of gene regulatory data along in vitro and in vivo B cell differentiation.
• She/he will supervise students and support grant applications.

How to apply

To apply for this opportunity, please send your resume and a cover letter (incl. the contact details of two referees) to [email protected] indicating in the subject of the message: REF.: PR_BJ_56.

Deadline for Applications

Please submit your application by the 28th  of August, 2021.