Postdoctoral fellow – protein interaction mutagenesis at scael

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies. 

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and theCode of Conduct for the Recruitment of Researchers (Charter and Code). 

Please, check out our Recruitment Policy

The role  

The successful applicant will work as part of a team to produce and analyse a very large dataset of how variants affect protein-protein binding affinity across many structurally diverse proteins.  The goal is to understand, predict and engineer sequence-to-affinity encoding using a combination of massively parallel mutagenesis and machine learning.

About the lab 

The Genetic Systems lab combines massively parallel mutagenesis and selection experiments with machine learning to tackle the foundational sequence-to-activity relationships of molecular biology and to make biology predictive and programmable.

Whom would we like to hire?  

Professional experience  

Must Have

• Experience in high-throughput biology, genomics or biophysics 

• You have proven experience with the organisation, execution and analysis of biological experiments at scale 

• Good understanding of statistic and bioinformatics

Desirable but not required/ Nice to have 

• Experience working with bacteria, yeast or mammalian cell culture 

• Experience in machine learning 

Education and training

• You hold a Phd in genomics, biophysics or a related discipline 

Languages

• You are proficient in English 

Technical skills

• Ability to plan, execute, organise the data from and analyse high throughput experiments 

• Statistics and computational biology

Competences  

• Highly developed organizational skills 

• Good written and verbal communication skills

• Ability to work as part of an interdisciplinary and diverse team 

• Ability to work to deadlines, plan and organise large-scale experimental data production 

The Offer – Working Conditions 

• Contract duration: Technical and scientific activities contract (estimated 1 year) 

• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales 

• Target start date:April 2024

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .

We offer and promote a diverse and inclusive environmentand welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion,sexual orientation or gender identity.

The CRG is committed to reconcile a work and family lifeof its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

All applications must be addressed to Dr. Ben Lehner and be submitted online through the "Apply" button below.

Selection Process  

• Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based. 

• Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required. 

• Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.  

Deadline: Please submit your application by April 12th, 2024.

The contract will be financed by ERC