Lab Technician at the Intracellular Compartmentation Lab

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

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The role

At the cell compartmentation group, we are looking for a new team member who will employ CRISPR, ShRNA and siRNA primarily in mammalian cells, to address the mechanism of collagen secretion. The candidate will be working on protein expression and purification for quantitative and structural analysis.

About the lab

The Intracellular compartmentation lab studies different aspects of protein secretion. Protein secretion is an old problem of fundamental interest in cell biology. While over the last decades a lot of progress has been made in understanding protein secretion, a number of questions remain unsolved. The lab aims to understand different aspects of this. On the one had they study the process whereby cytoplasmic, signal sequence lacking proteins are secreted from cells upon certain stimuli (known as unconventional protein secretion). On the other hand they focus on the transport and secretion of large, complex cargoes (like collagens and mucins) that do not fit the conventional secretory pathway.