COMPUTATIONAL BIOLOGY RESEARCHER

The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona. The IJC has laboratories in 4 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau and iii) Hospital Germans Trias and iv) Pujol and Hospital del Mar. IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia. The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.

Research Description

The Menendez´s Laboratory is located at the School of Medicine, Hospital Clinic in the city center. It is comprised by 15 excellent pre-clinical (wet) scientists at different stages of their careers (from PhDs to Senior Research Associates). Our main research interests are two-fold: i) to understand the etiology and pathogenesis of pediatric acute leukemias (both lymphoid and myeloid), and ii) to develop innovative T-cell immunotherapies for leukemia and sarcoma. Our lab uses cutting-edge technologies including human primary samples, animal models and xenografts, T-cell biology, hybridoma and CAR T-cell development, CRISPR-based gene editing, pluripotent stem cells and gastruloids etc. The group is a well-established and dynamic, constantly seeking scientific excellence and bench-to-bedside translational knowledge. We are funded by national and international agencies. Very important, we are affiliated to CIBERONC, TERAV (Red Española de Terapias Avanzadas), SEHOP (Spanish Society of Pediatric Hemato-Oncology) and ReALLNet (Spanish working group of relapsed/refractory acute leukemia patients).

We are searching for a highly motivated computational biologist with experience in R, Python etc and ‘omics’ who is specially interested in answering basic and translational biological questions in close collaboration with preclinical and clinical scientists. The selected candidate will be involved in the project “Next Generation Universal T-cell Redirected ImmunoTherapy for Acute Leukemia”

Please also visit our group webpage:

https://www.carrerasresearch.org/en/Stem_cells_mesenchymal_cancer_and_development

This project has been funded Fundación Asociación Española Contra el Cáncer (FAECC), under call Proyectos Generales AECC 2021, ref: PRYGN211192BUEN

Responsibilities include:

• Development of the tasks included in the project “Next Generation Universal T-cell Redirected ImmunoTherapy for Acute Leukemia”
• Analysis of integrative ‘omics’, mainly single-cell RNAseq, RNA-seq, ChIP-seq, exome, and whole genome DNA sequencing analysis.
• Analysis, statistics, and visualization of high biological and clinical datasets.
• Conduct data analysis and prepare data for presentation in peer-reviewed journals and professional meetings.
• Lead the humanization and proteomic structural analysis is CARa/scFv!