3-YEAR POSTDOC POSITION STUDYING CELLULAR SENESCENCE AND AGEING

1 Jun 2023
Job Information

Organisation/Company

Center for Biological Research "Margarita Salas"-CSIC

Department

Funding & Resources Unit

Research Field

Biological sciences

Researcher Profile

Recognised Researcher (R2)

Country

Spain

Application Deadline

15 Jun 2023 - 17:00 (Europe/Madrid)

Type of Contract

Permanent

Job Status

Full-time

Hours Per Week

37,5

Offer Starting Date

1 Sep 2023

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A postdoctoral contract is offered in the research group "Epigenetics and Cellular Senescence Lab" at the Center for Biological Research (CSIC) in Madrid. The contract will be carried out through the CSIC and will be charged to the project of the State Research Agency (Project PID2021-125656OB financed by MCIN/AEI/ 10.13039/501100011033/FEDER,UE).

Aging is a process of cellular and tissue dysfunction, which presents several characteristics, such as the activation of cellular senescence. Senescence is a process by which cells stop proliferating and produce a particular secretome. Our laboratory has recently identified that small extracellular vesicles (sEVs) serve as a cellular communication mechanism between senescent cells and proliferating cells. In this project, we propose to study the metabolomic changes produced during aging in human cells and in mouse tissues. For them, metabolomics, gene editing (CRISPR/Cas), proteomics and single-cell RNA sequencing (scRNAseq) studies will be carried out.

 

Requirements

Research Field

Biological sciences » Biology

Education Level

PhD or equivalent

Skills/Qualifications

For this, we are looking for a highly motivated person, capable of working independently, but also in a team. Experience in some of the following techniques will be valued, although it is not an essential requirement: use of primary cultures, infections with lentiviruses and/or retroviruses, isolation of extracellular vesicles and/or work with experimental animals. The scientific trajectory will also be valued, being beneficial to have a publication or paper under review by the first author.

Recent group posts:

1. Fafián-Labora J, ... O'Loghlen A. (2020) Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. Cell Metabolism 32(1):71-86.e5. Research highlight in Nat Rev Mol Cell Biol. Selected in “Focus in Aging” issue (Cell Metabolism).

2. Fafián-Labora J and O'Loghlen, A.* (2020) Classical and Nonclassical Intercellular Communication in Senescence and Aging. Trends in Cell Biology 30(8):628-39

 

3. Borghesan M, ... O'Loghlen, A*. Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence. 2019; Cell Reports 27, 3956–3971

 

Languages

ENGLISH

Level

Good

Research Field

Biological sciences » Biology

Additional Information
Benefits

The Center for Biological Research (CIB) is one of the most prestigious and historical research centers of the Spanish National Research Council (CSIC). Generations of distinguished scientists have carried out their research since the Center’s foundation in 1953, and new scientists continue to be trained there. In 2019, in homage to one of the most important researchers in the history of the CIB, where she spent a total of 13 years, and of Spanish molecular biology, the CIB was renamed the Margarita Salas Center for Biological Research.

Currently, the CIB Margarita Salas is reorganizing into three research programs, in which researchers study the structure and organization of living matter and its processes, seek to understand the bases of disease and discover experimental treatments and develop biotechnological processes to enable sustainable growth and facilitate agricultural production. We combine the generation of new knowledge with the development of applications that can help solve current and future challenges facing society.

Work Location(s)

Number of offers available

1

Company/Institute

Spanish National Research Centre (CSIC - CIB)

Country

Spain

State/Province

Madrid

City

Madrid

Postal Code

28040

Street

Calle Ramiro de Maeztu 9

Where to apply

E-mail

[email protected]

Contact

State/Province

Madrid

City

Madrid

Website

https://www.cib.csic.es/facilities/internal-services/funding-resources-unit
https://sites.google.com/view/theologhlenlab

Street

9th Ramiro de Maeztu,

Postal Code

28040

E-Mail

[email protected]

STATUS: EXPIRED