Research Fellow (Mechanobiology Institute)

13 Jan 2024
Job Information

Organisation/Company

NATIONAL UNIVERSITY OF SINGAPORE

Research Field

Biological sciences
Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Singapore

Application Deadline

11 Feb 2024 - 00:00 (UTC)

Type of Contract

Other

Job Status

Full-time

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Job Description

The Mechanobiology Institute (MBI), National University of Singapore is a multidisciplinary institute committed to developing new paradigms for biomedical research by focusing on the quantitative analysis of dynamic functional processes. Through quantitative biophysical approaches, we address major problems in biomedical sciences including pathogenesis (from bacterial to cancer), tissue regeneration, and function.

The Mechanobiology Institute seeks to recruit a Postdoctoral Fellow (Research Fellow) to join Asst. Prof. Jennifer Young’s Soft Nano-Biomaterials group. The group aims to characterize and recapitulate nanoscale extracellular matrix (ECM) properties of healthy and diseased tissues in order to better understand cellular behavior and clinical outcomes. Most diseases result in, or stem from, alterations in ECM. Yet, to date, nanoscale properties of tissues are poorly understood. This lack of knowledge on the tissue nanoenvironment poses a critical barrier to better understanding ECM-directed cellular behavior which can later be exploited for clinical applications.

The specific project in this call focuses on age-related ECM remodeling in the heart as part of the newly funded project M2CardAGE: Molecular and Mechanobiology Underpinning Cardiac Ageing. The chosen fellow will work toward imaging ex vivo tissue samples of young and aged hearts at high resolution using electron microscopy (EM) combined with immunogold labeling. This data will be compared to histological and mechanical analyses of matrix components to understand the links between observed age-related alterations and mechanobiological processes. Prior experience in EM and tissue handling techniques are a plus, but training can be organized if the candidate lacks experience in this domain. This project will ultimately result in a novel imaging workflow that can be applied across various disease models/tissue types, allowing for widespread relevance in numerous biological contexts.

The MBI and NUS provide state-of-the-art facilities dedicated to EM and high-resolution imaging that will support the fellow in training, setup, and execution of the project.

Qualifications

Candidates with a PhD in engineering, biology, biomedical sciences, or similar fields are encouraged to apply. They should have a strong background in ECM/ tissue biology, electron microscopy and/ or image analysis. Prior knowledge of EM and/ or tissue preparation are not a prerequisite but can be advantageous. The candidate should possess excellent communication skills and the ability to engage in collaborative research in a highly interdisciplinary environment.

Salary and benefits are commensurable to educational qualifications and working experience of the candidates.

To Apply

Applicants should also upload the following with their online application: 1) a brief description of research interests and experience, and 2) a full CV, with the names and contacts (email addresses) of two to three references.

We regret that only shortlisted candidates will be notified.

More Information
Location: Kent Ridge Campus
Organization: Mechanobiology Institute
Department : Mechanobiology Institute
Employee Referral Eligible: No
Job requisition ID : 22710

Requirements
Additional Information
Where to apply

Website

https://www.timeshighereducation.com/unijobs/listing/362990/research-fellow-mec…

STATUS: EXPIRED