Job Description
Project Title:
“Novel Precision Technologies to correct β-Thalassaemia Major: In vivo Adeno-Associated Viral vector (AAV)-mediated Base-Editing of the commonest Asian IVS1-5 (G>C) mutation in Haemopoetic Stem Cells (HSC), utilising engineered AAV, personalised Humanised”
The above-named project is funded by the National Medical Research Council, Ministry of Health. Our research focuses on delineating the factors that influence the safety and efficacy of intrauterine (fetal) therapy targeting major haemoglobinopathies. This therapy is promising in theory but has proven difficult to translate efficiently in preclinical and clinical models, with the main challenge being long-term and clinically relevant donor cell engraftment. Our group has developed a murine model of gene and stem cell therapy for thalassaemia major, our clinical target disease, and we seek a highly motivated scientist to join our team. The candidate should have knowledge of cell culture, molecular biology and animal handling. Promising and capable candidates who do not yet have the experience in these fields may also be considered.
Qualifications
Requirements
Interested parties please contact Lai Xin Hui Serene at [email protected]
More Information
Location: Kent Ridge Campus
Organization: Yong Loo Lin School of Medicine
Department : Obstetrics & Gynaecology
Employee Referral Eligible: No
Job requisition ID : 8276
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