Research Assistant (Member - doctoral student) & Scientific Researcher (Member - post-doctoral researcher)

23 Jan 2024
Job Information

Organisation/Company

Institute of Macromolecular Chemistry "P. Poni", Romanian Academy of Science

Department

CENTRE OF ADVANCED RESEARCH IN NANOBIOCONJUGATES AND BIOPOLYMERS

Research Field

Chemistry » Biochemistry
Chemistry » Other

Researcher Profile

First Stage Researcher (R1)
Recognised Researcher (R2)

Country

Romania

Application Deadline

23 Feb 2024 - 14:00 (Europe/Bucharest)

Type of Contract

Temporary

Job Status

Part-time

Offer Starting Date

4 Mar 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Type of employment contract: Individual part-time employment contract

Estimated contract start date: 01.03.2024

Employment period: temporary, until 31.12.2024 with the possibility of extension, with funding from “Intelligent systems for cancer diagnosis and treatment (IntelDots)” project, funding contract no. 760081/23.05.2023, CF 291/30.11.2022

The place of the research activity: Center of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru) laboratory within the “Petru Poni” Institute of Macromolecular Chemistry

Place of the competition: “Petru Poni” Institute of Macromolecular Chemistry (ICMPP), 41A Grigore Ghica Voda Alley, 700487 Iași

Requirements

Research Field

Chemistry » Other

Education Level

PhD or equivalent

Research Field

Chemistry » Biochemistry

Education Level

PhD or equivalent

Skills/Qualifications

Research  Assistant   position (Member - doctoral student):

• The candidate must possess a bachelor's and master's degree in one of the following fields chemistry/chemical engineering/biochemistry/biophysics/pharmacy/medicine and must be enrolled as PhD student within an institution organizing doctoral studies in Romania in chemistry/chemical engineering/physics/pharmacy/medicine;
• Evidence of competences demonstrated through diplomas, certificates, CV etc. in the field of preparaing nanoformulations for biomedical purposes and experience in carrying out in vitro/in vivo studies; proficiency in laboratory animal (rodent) care and handling techniques; experimental techniques for monitoring specific parameters in vivo;
• Theoretical and/or practical knowledge in in vitro/in vivo studies; Knowledge of legislation relating to the use of animals for scientific purposes; Knowledge of the ethical and legislative norms regarding the performance of in vivo studies; Competence in handling, transporting, and processing biological materials obtained from animals;
• Theoretical and/or practical knowledge in the formulation of preparations, respecting the specific protocols of pharmacology and molecular analysis;
• Intermediate knowledge of a foreign language, English mandatory, other international languages are an advantage;
• Willingness to travel domestically and internationally;
• Must possess motivation and creativity, along with advanced communication and teamwork abilities;
• Practical knowledge of computer software (Word, Excel, Power Point) is required. Familiarity with GraphPad and OriginLab is considered an advantage.

Research  Assistant   position (Member-doctoral student):

• The candidate must possess a bachelor's and master's degree in one of the following fields chemistry/chemical engineering/pharmacy and must be enrolled as PhD student within an institution organizing doctoral studies in Romania in chemistry/chemical engineering/pharmacy;
• Theoretical and practical knowledge in fine organic chemistry and organic structural analysis;
• Theoretical and practical knowledge in heterocyclic chemistry and oligopeptide chemistry;
• Intermediate knowledge of a foreign language, English mandatory, other international languages are an advantage;
• Willingness to travel domestically and internationally;
• Must possess motivation and creativity, along with advanced communication and teamwork abilities;
• Practical knowledge of computer software (Word, Excel, Power Point) is required. Familiarity with ChemDraw, Origin, MestReNova, ChemSketch, and ImageJ is considered an advantage.

Scientific  Researcher  (Member - post-doctoral  researcher):

• The candidate must have completed higher education, including a bachelor's and master's degree, in the fields of chemistry or chemical engineering;
• The candidate holds a doctor's degree in one of the previously mentioned fields and meet the criteria for being classified as a “post-doctoral researcher” as defined in Instruction no. 2260/15.11.2023 regarding the clarification of the definition of “post-doctoral researcher” within projects related to the investments of Component 9 “Support for the private sector, Research, Development and Innovation” of the National Recovery and Resilience Plan issued by the Ministry of Research, Innovation and Digitization: “the person who, on the date of the call, holds a doctor's degree and has experience in research of no more than 8 years full-time equivalent, from the date of the first doctoral degree, but not exceeding 10 years full-time equivalent under the conditions provided by the European Research Executive Agency (REA)”. *The date of the call refers to the date launch of the PNRR-III-C9-2022-I8 call, namely 15.09.2022. **If the doctoral degree was awarded by ministerial order, the date of the ministerial order shall be taken into account, otherwise the date indicated on the diploma shall be taken into account;
• The candidate must possess advanced proficiency in research methodologies - experimental synthesis techniques in organic and/or macromolecular chemistry, material characterization by physico-chemical methods (X-ray diffraction, XPS, NMR, MS, UV-Vis spectroscopy, FTIR);
• Experience in developing systems for drug/gene delivery applications is required. Familiarity with inorganic nanoparticles, fullerene derivatives, and cyclodextrin is considered an advantage;
• The candidate must possess skills in processing and presenting research findings;
• The candidate should have prior experience in preparing drafts/manuscripts for publication in scientific journals and in writing national/international project proposals The applicant is required to have a minimum of 5 publications published in journals that have an ISI impact factor;
• Intermediate knowledge of a foreign language, English mandatory, other international languages are an advantage;
• Willingness to travel domestically and internationally;
• Must possess motivation and creativity, along with advanced communication and teamwork abilities;
• Practical knowledge of computer software (Word, Excel, Power Point) is required. Familiarity with ChemDraw, Origin, MestReNova, ChemSketch, ImageJ, ACD Spectrus Processor, Match and crystallographic databases is considered an advantage.

 
Specific Requirements

Specific requirements for the Research  Assistant   position  (Member - doctoral student):

Job description : nanoformulations for biomedical use based on carbon nanostructures; in vitro and in vivo studies on the activity of carbon nanostructures by magnetic resonance (MRI) and fluorescence imaging; morphofunctional studies.

.......................................

Specific requirements for the  Research  Assistant   position  (Member-doctoral student):

Job description : synthesis and physicochemical characterization of intelligent systems based on carbon nanostructures, cyclodextrins, heterocyclic derivatives and peptides.

.......................................

Specific requirements for the Scientific  Researcher   position  (Member - post-doctoral researcher):

Job description : synthesis and physicochemical characterization of intelligent systems based on carbon nanostructures, cyclodextrins and peptides.

Languages

ENGLISH

Level

Excellent

Languages

ROMANIAN

Level

Excellent

Research Field

Chemistry » Biochemistry

Additional Information
Eligibility criteria

General requirements for candidates:

• The candidate must hold Romanian citizenship, citizenship of other European Union member states, or citizenship of states belonging to the European Economic Area, and must have residency in Romania;
• The candidate must have proficiency in both written and spoken Romanian;
• The candidate must also have proficiency in English, and in the case of foreign citizens, must provide a certificate of linguistic recognition for the Romanian language at the B2 level;
• The candidate has full exercise capacity;
• The candidate has a state of health corresponding to the position for which he/she is applying;
• The candidate is medically fit;
• The candidate is available for full-time employment for a fixed period.

Selection process

Research Assistant position 1(Member - doctoral student):â

Analysis of the candidate's file and oral examination – presentation of the scientific activity of the candidates. Only candidates who have submitted all the necessary documents to register for the competition and meet the participation conditions are accepted to participate at the oral examination. The results of the selection of competition files are displayed with the mention “admitted” or “rejected”. The oral examination will take place at the ICMPP headquarters. Each member of the competition committee will give marks between 1 and 10 individually. The final grade represents the arithmetic mean of the marks given by each member of the committee. Ranking of candidates will be done according to the final average grade.

Examination topics:

Laboratory preparation of various nanoformulations: metal/lipid nanoparticles, micelles, vesicles, liposomes, micro-/nanoemulsions, nanosuspensions

Characterization methods of nanoformulations

Separation/purification methods of chemical compounds: evaporation, filtration, centrifugation, column/thin layer chromatography, dialysis, liquid chromatography (LC)

Spectral techniques for substance characterization and applications: FTIR, UV-Vis, fluorimetry, mass spectrometry, NMR applicable to nanoformulations

Imaging evaluation methods of chemical products by using phantoms

Solutions and suspensions preparation for laboratory animals administration

Qualitative and quantitative control of suspensions and solutions

Maintenance and handling techniques of laboratory animals. Animal welfare in scientific research.

Ethical guidelines for doing studies on laboratory animals (mice and rats).

Bibliography:

Popovici I . Lupuleasa D. Tehnologie farmaceutică, Volumul I, Ediția a IV-a, Polirom, 2017 ( Tratat).

Popovici I . Lupuleasa D. Tehnologie farmaceutică, Volumul II, Ediția a IV-a, Polirom, 2017 (Tratat).

OECD (2002), Test No. 423: Acute Oral toxicity - Acute Toxic Class Method, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris.

OECD (2008), Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris.

Guide for the Care and Use of Laboratory Animals, The National Academies Press, Washington DC,2011.

Stanciu GD, Coman C. Tratat de medicină experimentală: șoareci și șobolani de laborator. Editura ”Gr. T. Popa”, Iași, 2022. ISBN: 978-606-544-734-9.

Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes.

SR EN ISO/IEC: 17025:2018 „Cerințe generale pentru competenta laboratoarelor de încercări si etalonări”.

Bernard Valeur, Molecular Fluorescence: Principles and Applications, 2001, Wiley -VCH Verlag GmbH

Iuliu Pogany, Mircea Banciu, Metode fizice în chimia organică, Ed. Științifică, Buc., 1972

Vladimir P. Torchilin, Nanoparticulates as drug carriers, Imperial College Press, London, 2006

Heinz Becker et al., Organicum. Chimie organică practică, Ed. Științifică și Enciclopedică, Buc., 1982.

 

.......................................

Research Assistant position 2 (Member-doctoral student):

 

Selection procedure:Analysis of the candidate's file and oral examination – presentation of the scientific activity of the candidates. Only candidates who have submitted all the necessary documents to register for the competition and meet the participation conditions are accepted to participate at the oral examination. The results of the selection of competition files are displayed with the mention “admitted” or “rejected”. The oral examination will take place at the ICMPP headquarters. Each member of the competition committee will give marks between 1 and 10 individually. The final grade represents the arithmetic mean of the marks given by each member of the committee. Ranking of candidates will be done according to the final average grade.

Examination topics:

Synthesis and chemistry of azaheterocyclic organic compounds from the pyridazine class

Synthesis and chemistry of azaheterocyclic organic compounds from the phthalazine class

Basic concepts on cycloammonium ylides

Basic concepts about amino acids and oligopeptides

Spectral techniques used to characterization substances and applications: FTIR, UV-Vis, mass spectrometry, 1 H-NMR, 13 C-NMR, one and two-dimensional correlations

Bibliography:

Neniţescu, C.D. Chimie Organică, Vol. I, II, Ed. Didactică şi Pedagogică, Bucucureşti, 1980.

Ege, Seyhan. Organic Chemistry, 4th Edition, Hugton-Mifflin, 1998;

Solomons, T.W.G. Fundamentals of Organic Chemistry, 5th Edition, John Wiley & Sons, New York/ Chichester/Brisbane/Toronto/Singapore, 1992

Avram, M. Chimie Organică, Ed. Zecasian, Bucucureşti,1999.

Vollhardt, K.P.C.; Schore, N.E.; Organic Chemistry, W.H. Freeman and Company, New York, 2002.

Sunel, V., Chimie organică. Compuși heterociclici. Produsi naturali. Ed. Universităţii,  “Al.I.Cuza”-Iasi, 1995.

Silverman, R.B. The Organic Chemistry of Drug Design and Drug Action, Academic Press, New York,1992.

R. M. Silverstein, F. X. Webster, D. J. Kiemle, D. L. Bryce, Spectrometric Identification of Organic Compounds (8th edition), John Wiley & Sons, Ltd, 2014.

 

..........................................

Scientific Researcher (Member - post-doctoral researcher):

Selection procedure:Analysis of the candidate's file, written test (examination topics shown on the website), and oral examination – presentation of the scientific activity of the candidates. Only candidates who have submitted all the necessary documents to register for the competition and meet the participation conditions are accepted to participate at the oral examination. The results of the selection of competition files are displayed with the mention “admitted” or “rejected”. Only candidates who obtained at least an average of 8 and no grade below 7 are accepted to participate at the oral examination. The oral examination will take place at the ICMPP headquarters. Each member of the competition committee will give marks between 1 and 10 individually. The final grade represents the arithmetic mean of the marks given by each member of the committee. Ranking of candidates will be done according to the final average grade.

Examination topics:

1. Notions of organic chemistry

1.1. Electrophilic addition to the double connection

1.2. Radical addition to the double connection

1.3. SN1 nucleophilic substitution in halogenated compounds

1.4. SN2 nucleophilic substitution in halogenated compounds

2. Cyclodextrins

2.1. Definition, structure, classification

2.2. Physical and chemical properties

2.2. Complexes of inclusion

3. Chemical reactions of macromolecular compounds

3.1. Polymer-analog transformations

3.2. The reaction capacity of functional groups belonging to macromolecular chains.

Bibliography:

1.Neniţescu, C.D. Chimie Organică, Vol. I, II, Ed. Didactică şi Pedagogică, Bucucureşti, 1980.

2.M.Avram,. Chimie Organică, Ed. Editura Academiei Române, București,1983, vol. 1,2.

3.F. Badea, Mecanisme de reacție în chimia organică, Editura Stiințifică, Bucuresti, 1973.

4.C.I. Simionescu , C. Vasiliu Oprea, V. Bulacovschi, B.C. Simionescu, C. Negulianu, Chimie macromoleculară, Ed. Didactică și Pedagogică, Bucuresti, 1985.

5.J. Szejtli, Cyclodextrins and their inclusions complexes, Akademiai Kiado, Budapest, 1982

 

Additional comments

Competition timetable:

 

Competition publication date: 23.01.2024

Deadline of the files submission: 23.02.2024, 12.00 at the ICMPP headquarters or online at the address: [email protected]

Publication of the results on the files analysis: 23.02.2024, ora 16.00

Appeals of the results on the files analysis must be submitted until: 26.02.2024, ora 14.00

Publication of the final results on the file analysis on the institute's website: 26.02.2024, ora 16.00

For the Research Assistant positions:

Oral examination date: 27.02.2024, ora 11,00.

Date of publication of the results of the oral examination: 28.02.2024, ora 14.00

Appeals of the results on the oral examination must be submitted until: 29.02.2024, ora 14.00

Publication of the final results on the oral examination on the institute's website: 01.03.2024, ora 14.00

For the Scientific Researcher position:

Written test date: 27.02.2024, ora 10,00;

Date of publication of the results of the written test: 27.02.2024, ora 16.00

Appeals of the results on the written test must be submitted until: 28.02.2024, ora 14.00

Oral examination: 29.02.2024, ora 11,00.

Date of publication of the results of the oral examination: 29.02.2024, ora 16.00

Appeals of the results on the oral examination must be submitted until: 01.03.2024, ora 14.00

Publication of the final results on the oral examination on the institute's website: 01.03.2024, ora 14.00

 

The enrolment file must contain the documents provided by art. 15 alin. (6) from Law no. 319/2003 regarding the Statute of research and development personnel and the legislation in force, namely:

• The candidate must submit a formal request addressed to the ICMPP management by which he requests the registration in the competition for filling the vacant position, dated and signed by the candidate, approved by the director of the institute and registered within the legal registration deadline;
• Copy of identity document and copies of documents certifying the change of name, if applicable;
• Copies of the documents certifying the candidate's studies: bachelor's and/or master's degree accompanied by the transcript (academic reports or diploma supplement);
• Diplomas obtained in other states must be recognized by the National Council for Attestation of University Titles, Diplomas and Certificates (CNATDCU);
• Certificate attesting the quality of doctoral student enrolled in an institution organizing doctoral studies in Romania for the positions of research assistant - doctoral student;
• Annex 9 – Agreement of the doctoral supervisor (model displayed on the website) filled and signed for the position of research assistant - doctoral student;
• Copy of Doctor's diploma, for the position of scientific researcher - postdoctoral student;
• Curriculum vitae adapted to employment requirements;
• List of scientific contributions accompanied by evidence (where applicable);
• Cover letter (free format) in which to indicate the research areas of interest and the motivation for applying for the position;
• Medical certificate in original, attesting clearly the state of health, the number, date, name of the issuer and its quality, in the standard format established by the Ministry of Health;
• Criminal record or declaration on his own responsibility that he/she has no criminal convictions that would make him/her incompatible with the position for which he/she is applying, with the completion of the competition file (up to the date of the first competition test) with the original criminal record.

Website for additional job details

https://icmpp.ro/concursuri.php

Work Location(s)

Number of offers available

3

Company/Institute

Institutul de chimie Petru Poni

Country

Romania

State/Province

Iași

City

Iași

Postal Code

700487

Street

al. Grigore Ghica Voda, nr. 41A

Geofield

Where to apply

E-mail

[email protected]

Contact

State/Province

Iași

City

Iași

Website

http://www.icmpp.ro

Street

al. Grigore Ghica Voda, nr. 41A

Postal Code

700487

E-Mail

[email protected]

Phone

0332880220

STATUS: EXPIRED