CALL FOR RESEARCH FELLOWSHIP – Lugus 989062 Grant Agreement n.º 101080229

15 Apr 2024
Job Information

Organisation/Company

Universidade de Coimbra

Department

Divisão de Projetos e Atividades (Bolsas)

Research Field

Other

Researcher Profile

First Stage Researcher (R1)

Country

Portugal

Application Deadline

14 May 2024 - 23:59 (Europe/Lisbon)

Type of Contract

Permanent

Job Status

Full-time

Hours Per Week

35

Is the job funded through the EU Research Framework Programme?

HE

Reference Number

Grant Agreement n.º 101080229

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

University of Coimbra opens a call for one research fellowship, in the framework of the DREAMS project “Drug REpurposing with Artificial intelligence for Muscular disorderS” (reference: Grant Agreement n.º 101080229), financed by European Union’s Horizon Europe
research and innovation programme under grant agreement N.º 101080229,in the following conditions:

Scientific area: Cell and Molecular Biology, Biomedical Research, Biomedical Research, Biochemistry, Pharmaceutical Sciences.

Skills/Qualifications/Admission requirements: Academic degree in the scientific area Cell and Molecular Biology, Biomedical Research, Biomedical Research, Biochemistry, or Pharmaceutical Sciences.

Candidates should develop their experimental master's thesis in 2024 and with theoretical training in cellular and molecular biology and/or biomedical research and/or biomedical engineering and/or biochemistry and/or pharmaceutical sciences.
Research Initiation Fellowships cannot be awarded to those who have already benefited from research fellowships directly or indirectly financed by the FCT (regardless of the type).
Furthermore, this (these) fellowship(s) can only be awarded to those who do not exceed, with the conclusion of the contract in question, including possible renewals, an accumulated period of one year in this type of fellowship, consecutive or interpolated.
Although the recipients must be enrolled in a cycle of studies leading to the attribution of an academic degree or in a course not conferring an academic degree, at the time of application it is not necessary for the candidate to have made such an enrollment, and proof of enrollment must be presented until the fellowship is contractualized. Candidates are only required to meet the requirements to enroll in the training offer. If there are candidates already enrolled (including attending a course), they compete on an equal footing with those who are not enrolled.

Work plan/ Objectives: The candidate will contribute for:
1- Characterization of the phenotype of muscle cells with Pompe disease [1, 2]. In this task, immortalized cells with the disease as well as skeletal muscle cells differentiated from iPSCs derived from patients with Pompe disease will be characterized. The cells will be characterized regarding their lysosomal dysfunction and glycogen accumulation capacity.
2- Characterization of the phenotype of the disease in muscle biopsies. In this task, muscles from mice and human patients with the disease will be characterized according to the phenotypical markers tested in task 1.
3- Test pharmacological interventions to reverse the disease phenotype. In this task, some drugs from members of the consortium as well existing formulations in the UC laboratory will be investigated on skeletal muscle cells differentiated from iPSCs derived from patients with Pompe disease.

Regime: The attribution of the fellowship does not generate or entitle a relation of a legallabour nature, and the fellowship is undertaken in an exclusive dedication regime. The fellowship holder is awarded the Fellowship Statute of the UC, in its current wording, according to the Research Fellowship Holder Statute , and according to the Regulation for Research Fellowships of the Foundation for Science and Technology, both in their current wording.

Location: UC-Biotech at the University of Coimbra.

Duration: 6 (six) months.

Renewal: Eventually renewable and cannot exceed the end of the project.

Scientific orientation: Lino da Silva Ferreira.

Financial conditions: The amount of the fellowship is € 601,12 (six hundred and one euro and twelve cents corresponding to the monthly compensation stipulated in the FCT table (https://www.fct.pt/en/financiamento/programas-de-financiamento/bolsas/ ), plus social security (Seguro Social Voluntário, first level contributions) and personal accidents insurance.
The payment will be made by bank transfer. This amount will not be increased during the entire period of the fellowship duration.

Selection methods: Curricular Evaluation (50%) and Interview (50%).

Selection criteria: The following criteria will be considered in curricular evaluation:
- Asbolute merit of curriculum vitae (75%);
- Specific knowledge related to the work plan (25%).

For the Interview, the following criteria will be considered:
- Ability to express oneself and verbal fluency (40%);
- Motivation and Interest (60%).

The Selection Jury reserves the right not to select any candidate if it is verified that none has the appropriate profile to carry out the functions.

Jury responsible for selection:
President: Lino da Silva Ferreira
Effective Vowel: Susana Carvalho Rosa
Effective Vowel: Luís Miguel Beicinha Branco Estronca
Substitute Vowel: Patrícia Raquel Pinheiro Pitrez Pereira
Substitute Vowel: Susana Margarida Neto Simões

Formalization of application: Applications must be formalized by sending the following documents:
- Motivation Letter;
- Curriculum Vitae, and
- Declaration mentioned below.

Declaration on the honor of the candidate(s) with the indication of the fellowship(s) of the typology to which the contest was held and the respective duration(s).
Applicants with academic degrees obtained abroad will be required to present a Certificate of Recognition in accordance with applicable law. This document is mandatory only in the contractualization phase.

Applications submission: Applications must be submitted in https://apply.uc.pt .

Submission of applications: Between 16/04/2024 and 14/05/2024.

Submission deadline date: 14/05/2024.

Additional information: The evaluation results will be announced within 90 working days after the end of the applications submission deadline, by notifying the applicants via email.
After the announcement of the results, candidates are considered automatically notified to, if they wish to do so, comment on the results on a preliminary hearing period within 10 days after that date. After this, the selected candidates will have to declare in writing their acceptance. Unless a justification worthy of consideration is presented, if the declaration is not submitted within the referred period, it is considered that the candidate waivers the fellowship.
In case of resignation or withdrawal of the selected candidate, the next candidate with the highest evaluation score will be notified immediately.
Once the selection process is completed, the fellowship contract will be drawn up in accordance with the draft contract provided by the FCT.
After the contracted period, the fellowship holder and supervisor must prepare the final report in accordance with the respective assessment criteria that were established.
Pursuant to subparagraph h) of Article 9 of the Portuguese Constitution, the University of Coimbra, as employer, actively promotes a policy of equal opportunities between men and women in access to employment and professional development, and acts to prevent each and every kind of discrimination.
Therefore, no one can be privileged, benefited, harmed or deprived of any right or immune from any duty on account of, in particular, ancestry, age, sexual orientation, gender, marital status, family, economic situation, education, origin or social condition, genetic heritage, reduced work capacity, disability, chronic illness, nationality, ethnic or racial origin, territory of origin, language, religion, political or ideological beliefs and trade union membership.

Selection reserve list: N.A

Requirements

Research Field

Other

Education Level

Bachelor Degree or equivalent

Additional Information

Website for additional job details

https://app-2.0.apply.uc.pt/procedure/IT137-24-186

Work Location(s)

Number of offers available

1

Company/Institute

Universidade de Coimbra

Country

Portugal

State/Province

Coimbra

City

Coimbra

Postal Code

3004-504

Street

Rua Larga Edifício, FMUC, 1.º piso, Polo I;

Where to apply

Website

https://apply.uc.pt

Contact

City

Coimbra

Website

https://www.uc.pt/administracao/dpa

Street

Rua Larga Edifício, FMUC, 1.º piso, Polo I;

Postal Code

3004-504

E-Mail

[email protected]

STATUS: EXPIRED