Laboratory of Cell Biology https://bit.ly/3ptdp4V at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), headed by Professor Marta Miączyńska is looking for a Postdoctoral Researcher.
You will join the project entitled “AXL receptor signaling in cancer cell growth and drug resistance” carried out as the OPUS grant (DEC-2020/39/B/NZ3/03429) of the National Science Centre, Poland.
The project aims to investigate the molecular mechanisms of AXL receptor signaling that regulates cancer cell growth. Specifically, we will study how the AXL receptor and its ligand GAS6 stimulate uptake of nutrients from the extracellular environment via macropinocytosis. We will also determine whether and how this phenomenon contributes to drug resistance of cancer cells and, consequently, to the growth of tumors despite the applied therapy. The project is based on our previous studies in which we identified the AXL receptor interactome and discovered that AXL binds numerous proteins that regulate actin cytoskeleton dynamics. Through such interactions, activation of AXL receptor stimulates the formation of peripheral and circular membrane ruffles that promote macropinocytosis and ultimately lead to cell invasion (see the preprint of our manuscript at https://bit.ly/3fFHeLo for more details).
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