15 Mar 2024
Job Information
- Organisation/Company
Adam Mickiewicz University, Poznań- Department
Department of Gene Expression- Research Field
Biological sciences » Biology
Biological sciences » Other- Researcher Profile
Recognised Researcher (R2)- Country
Poland- Application Deadline
30 Apr 2024 - 23:59 (Europe/Warsaw)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Offer Starting Date
1 Jul 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Project leader: Prof. Krzysztof Sobczak
Project title: Pathogenesis driven by RNAs with expansion of trinucleotide repeats: mechanisms and therapeutic strategies
Project is carried out within the MAESTRO programme of the National Science Center.
Position for PostDoc available at the Department of Gene Expression, Institute of Molecular Biology and Biotechnology (IMBB), Faculty of Biology, Adam Mickiewicz University in Poznań (AMU). AMU is the largest academic center in Poznań and one of the best research centers in Poland (ID-UB status).
We are looking for people interested in research work in a team dealing with research related to human molecular genetics, under the direction of Professor Krzysztof Sobczak. The team's interests focus primarily on the study of the molecular basis and the development of experimental therapy for selected neurodegenerative diseases associated with trinucleotide repeat expansion (myotonic dystrophies - DM, and fragile X-associated syndromes - FXS and FXTAS).
DM1 is an autosomal dominant disorder caused by CTG repeat expansion in the 3'-UTR of the DMPK gene. The DMPK transcript contains extended CUG repeats (CUGexp) and is retained in the nucleus in the form of nucleoprotein clusters (foci). This nuclear retention of the DMPK transcript is in part a consequence of the interaction of CUGexp RNA with RNA binding proteins, such as splicing factors belonging to the Muscleblind-like protein (MBNL) family. The binding of hundreds of MBNL proteins to a single CUGexp RNA results in their functional deficiency and disruption of alternative splicing, a process normally regulated by these proteins.
In our research, we focus on a deeper understanding of some aspects of the molecular basis of DM (CUGexp) and FXTAS (CGGexp), especially those related to metabolism of toxic RNAs, the functions of individual splicing factors, and disturbances in non-canonical translation occurring directly on the sequence of trinucleotide repeats (the so-called RAN translation). We also focus on the development of therapeutic approaches using antisense oligonucleotides (ASOs) and small compounds that prevent the interaction of CUGexp (DM) and CGGexp (FXTAS) RNAs with proteins.
Basic duties:
- Conducting experiments explaining the mechanisms of RNA recognition by MBNL proteins and the regulation of alternative splicing by these proteins based on whole transcriptome approaches.
- Conducting experiments explaining the mechanisms of RAN translation of CGGexp in the FMR1 mRNA – cell-base experiments and whole transcriptome approaches.
- Experimental therapy of DM1 and FXTAS with the use of ASO and small compounds both in vitro and in animal models of these diseases.
- Participation in the preparation of publications.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- PhD or equivalent
- Research Field
- Biological sciences » Other
- Education Level
- PhD or equivalent
Skills/Qualifications
- Languages
- ENGLISH
- Level
- Good
Additional Information
Benefits
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- funding for language learning
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salar
Eligibility criteria
Selection process
Additional comments
- Application form/letter of the candidate;
- Professional CV including scientific achievements;
- Diplomas or certificates issued by colleges and universities attesting to education and degrees or titles held (in case of academic degrees obtained abroad - the documents must meet the equivalence criteria set out in Article 328 of the Act of 20 July 2018 Law on Higher Education and Science (Journal of Laws of 2023, item 742 i.e.; Polish: Dziennik Ustaw 2023 poz. 742 tj.);
- Information on the Applicant’s research, teaching and organizational achievements;
- List of publications;
- Letter summarizing previous work, experience and future interests;
- Contact information for two professional references;
- Candidates will be selected through an open competition in accordance with the guidelines of the National Science Centre;
- The competition may be extended until a suitable candidate is found who meets all the requirements.
- Consent to the processing of personal data as follows : In accordance with Article 6 (1) (a) of the General Data Protection Regulation of 27 April 2016. (OJ EU L 119/1 of 4 May 2016) I consent to the processing of personal data other than: first name, (first names) and surname; parents' first names; date of birth; place of residence (mailing address); education; previous employment history, included in my job offer for the purpose of the current recruitment.";
RODO Information Clause :
Pursuant to Article 13 of the General Data Protection Regulation of 27 April 2016. (Official Journal of the EU L 119 of 04.05.2016) we inform that:
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań
- Country
- Poland
- City
- Poznan
- Postal Code
- 61-614
- Street
- Uniwersytetu Poznańskiego 6
- Geofield
Where to apply
[email protected]
Contact
- State/Province
Wielkopolska- City
Poznań- Website
http://ibmib.home.amu.edu.pl/en/main-page/- Street
Wieniawskiego 1- Postal Code
61-712
[email protected]
STATUS: EXPIRED
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