12 Jan 2024
Job Information
- Organisation/Company
Adam Mickiewicz University, Poznań- Research Field
Biological sciences » Biology
Chemistry » Biochemistry
Engineering » Materials engineering- Researcher Profile
Recognised Researcher (R2)- Country
Poland- Application Deadline
10 Feb 2024 - 23:59 (Europe/Athens)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Offer Starting Date
1 Mar 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Reference Number
SONATA 18 UMO-2022/47/D/ST8/03467- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The job offer refers to the position in the SONATA project (National Science Center) titled “Development and characterization of a novel bioink for fabrication of 3D printed bioartificial pulsatile prosthesis for applications in tissue engineering – PulsBioInk” (Contract number: 2022/47/D/ST5/03467) under the supervision of dr Jagoda Litowczenko-Cybulska.
The aim of the project is to establish conditions for development of mechanically stable 3D printed stents which will be act as biocompatible biomimetic constructs containing human cardiomyocytes and endothelial cells. The main goal of the Sonata PulsBioInk project is to produce novel innovative bioimplants using the highly reproducible 3D bioprinting technique.
The project involves the use of the combination polymers of natural and synthetic origin to produce the novel bioink for direct 3D printing of cell constructs. Natural polymers based on silk fibroin with unique biological properties and mechanical properties, biodegradability, biocompatibility and bioresorbability will be used in combination with synthetic polymers with specific fiber architecture, aimed at improving the stability and mechanical properties of the scaffolds. The detailed impact of 3D-bioprinted grafts on encapsulated cell behavior as well as interactions between two types of human cells (cardiomyocytes and endothelial cells) will be studied in vitro and in a designed ex vivo bioreactor system.
Cardiovascular diseases (CVD) are one of the leading causes of death worldwide, leading to 17.9 million deaths each year. CVD is a general term covering a wide range of disorders of the heart and blood vessels that most commonly affect people over the age of 60. Congenital heart disease (CHD) is one of the causes of chronic CVD, which is the most common cause of congenital pathologies and the most common congenital malformation, affecting almost 1% of all live births. In 2019, CHD was the leading cause of 217,000 deaths, of which 150,000 deaths were in infants under 1 year of age. A quarter of children affected by coronary heart disease will require major reconstructive surgery in their lifetime. Although significant improvements have been made in the treatment of congenital heart defects in recent decades, they remain the leading cause of death in the neonatal period. In the treatment of CHD, grafts made of synthetic materials such as polytetrafluoroethylene (PTFE or Gore-Tex) are used, which are prone to strictures, thromboembolism and infections. Graft failure rates have been reported to be 70 to 100% over 10 years. Therefore, patients require a series of reoperations to replace failed grafts, each of which is associated with mortality. Vascular tissue engineering provides a potential solution to these limitations.
The project aims to produce a highly stable for long-term culture cellular prosthesis construct that can be used as a model for testing/or treatment of cardiovascular diseases in the future. The project will be realized at the NanoBioMedical Centre (NBMC) AMU in cooperation with mainly University of Michigan.
The postdoctoral scientist will mainly be responsible for iPSC cell culture and differentiation, characterisation (PCR, Western Blots, ICC), biofabrication of cell-laden 3D bioprinted constructs, their maintenance and characterization.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- PhD or equivalent
- Research Field
- Chemistry » Biochemistry
- Education Level
- PhD or equivalent
- Research Field
- Engineering » Materials engineering
- Education Level
- PhD or equivalent
Skills/Qualifications
The competition is open to individuals who meet the requirements specified in Article 113 of the Law on Higher Education and Science of 20 July 2018 (Journal of Laws of 2023, item 742, Article 113 as amended) and who meet the following requirements:
-Proven experience in human induced pluripotent stem cells culture, differentiation and characterisation (PCR, Western Blot).
- Expirience in 3D bioprinting and chemical characterisation of hydrogels (FTIR, UV/VIS spectrophotometer) will be an additional advantage.
- Knowledge of stem cell biology, molecular biology techniqs, proteomics, Real-Time PCR, confocal microscopy methods.
- Independence, good organization of work, ability to work in a team.
- Experience in writing scientific publications and conference presentations.
- Excellent knowledge of relevant software such as: OriginLab, Fiji.
- Experience with working in an international environment will be highly appreciated
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences » BiologyChemistry » BiochemistryEngineering » Materials engineering
- Years of Research Experience
- 4 - 10
Internal Application form(s) needed
zał 1_konkurs NA ogłoszenie_ENG_SonataJL_popr30 12.pdf
English
(301.2 KB - PDF)
Download
Additional Information
Benefits
- financial bonuses for high-impact publications
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- co-financing of language learning courses
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salary
Eligibility criteria
Selection process
Additional comments
RODO Information Clause :
Pursuant to Article 13 of the General Data Protection Regulation of 27 April 2016. (Official Journal of the EU L 119 of 04.05.2016) we inform that:
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- NanoBioMedical Centre
- Country
- Poland
- State/Province
- wielkopolska
- City
- Poznań
- Postal Code
- 61-614
- Street
- Wszechnicy Piastowskiej 3
- Geofield
Where to apply
[email protected]
Contact
- State/Province
Wielkopolska- City
Poznań- Website
http://www.amu.edu.pl- Street
Wieniawskiego 1- Postal Code
61-712
[email protected]
STATUS: EXPIRED
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