A postdoctoral researcher in optical imaging of in vitro models of cancer chemotherapy

Updated: 3 months ago
Job Type: FullTime
Deadline: 09 Jul 2021

Job purpose:

We seek an excellent candidate with experience in cancer biology, tissue culture, or optical imaging to work on experimental in vitro models of cancer chemotherapy. The candidate will investigate differences in single-cell response of normal and cancer cells to chemotherapy, and how the response correlates with phenotypic, non-genetic heterogeneity prior to treatment. The project will help to better understand why chemotherapy fails, quantify the contribution of different mechanisms leading to resistance, and drive better, predictive mathematical models of cancer treatment.

This post is funded through the POLS grant “Phenotypic heterogeneity in cancer chemotherapy” carried out in collaboration with Professor Hesso Farhan, the Institute of Basic Medical Sciences at the University of Oslo, and the Institute of Pathophysiology, Medical University of Innsbruck in Austria.

Main responsibilities:

1. Undertaking research projects in pursuit of goals agreed with the supervisor. This will involve deciding (with the supervisor) on the detailed direction of the research, formulating a strategy for day-to-day research work, implementing the strategy (without close supervision) and reporting progress to the supervisor and other research team members.

2. Communicating research strategies and results to team members and collaborators through talks and discussions, as well as learning about others’ research through seminars and journal clubs.

3. Assisting with supervision of junior researchers (Master and PhD students), where appropriate.

4. Writing reports and scientific papers.

5. Attending and presenting at workshops and conferences.

The candidate is expected to work closely with experimentalists from Prof. Hesso Farhan’s group (Innsbruck, Austria).

About the Dioscuri Centre:

The Centre’s main objective is to better understand the growth and evolution of pathogenic cells in human diseases from the chemistry and physics viewpoint. While most of the group works on bacterial infections, the Centre is also developing a research programme in cancer biology. In particular, we would like to improve the knowledge of mechanisms that lead to resistance to cancer chemotherapy. The members of the Centre use experimental in vitro models, computer simulations and mathematical theory to create data driven, quantitative models of bacterial infections and cancer. We anticipate that these models can help to develop new treatment modalities. To facilitate translation from the bench to the bedside, the Centre will collaborate with biomedical researchers and with industrial partners.

The Centre is co-funded by the Polish Ministry of Science and Higher Education and the German Federal Ministry of Education and Research, with additional support coming from NAWA and POLS.

The Centre is located in the Institute of Physical Chemistry (IPC, Polish: IChF), Polish Academy of Sciences, Warsaw, Poland.

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