Postdoctoral Fellow - Gene editing in haematological disease (ref 229749)

Are you interested in clinical utilization of CRISPR gene editing?

We are seeking a postdoctoral fellow to join our research team in facilitating the transition of one of our research projects into clinical testing. The position is affiliated with the Institute of Clinical Medicine at the University of Oslo, but your daily work place will be at Oslo University Hospital, Rikshospitalet and Norwegian Centre for Molecular Medicine at Oslo Science Park. 

In the project, you will work on a bleeding disorder called inherited factor (F) VII deficiency. FVII is a vital protein in the blood coagulation process and an inherited deficiency of this protein is caused by mutations in the F7 gene leading to severely reduced activity of the FVII protein in the blood. Clinically, these patients experience frequent and sometimes severe bleeding episodes, and the only treatment today is replacement therapy that is expensive and invasive. We are using CRISPR gene editing and advanced cell reprogramming techniques to correct the mutation in the patients’   and establishing transplant procedures to restore FVII activity and function. Your role will be to further optimize gene editing protocols, study the approach in preclinical animal models, and later transfer procedures into a GMP-compliant setting to ensure that the gene edited cells fulfill the requirements as Advanced Therapy Medicinal Products (ATMPs).

For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/229749/postdoctoral-fellow-gene-editing-in-haematological-disease