Technician molecular neuro-immunology of pain

23 Feb 2024
Job Information

Organisation/Company

University Medical Center Utrecht (UMC Utrecht)

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)

Country

Netherlands

Application Deadline

7 Mar 2024 - 22:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Our research aims to understand mechanisms of chronic pain. We specifically focus on the communication between the immune and nervous system and mitochondria. We recently discovered that mitochondria are important in regulating pain. Mitochondria not only regulate sensory neuron function, macrophages also donate their mitochondria to sensory neurons to control pain. In addition, we have found that a mitochondrial methyltransferase pain protein promotes chronic pain development. In this 2-year project you will investigate downstream targets of this protein in sensory neurons and macrophages/microglia using in vitro and in vivo strategies. You will use different molecular approaches including high-resolution mass spectrometry-based proteomics. In addition you will perform functional in vitro assays, such as assessment of macrophage function and mitochondrial activity in sensory neurons to assess identified targets. Finally you will aid with in vivo gene targeting strategies to assess the contribution of the target protein in regulation of chronic pain in different murine pain models.

Requirements
Specific Requirements

We are looking for talented and highly motivated research technician with a HBO degree in laboratory sciences, with expertise in molecular biology. You have excellent experimental skills and experience in cloning, cell culture, flow cytometry, ELISA’s and immunoprecipitation experiments. Affinity with neuro-immunology, molecular techniques, and mitochondrial assays is a plus. The willingness and certification to perform animal experiments is not a requirement, but would be appreciated. You should have good communication skills, flexible and good team player.

You should have good communication skills, organizational talent, flexible, versatile and a good team player.

Your application should include a motivation letter, a CV, and a brief description of past work experience.

Additional Information
Benefits

The maximum salary for this position (28 - 36 hours) is € 4.052,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Additional comments

Contact our colleague:
Niels Eijkelkamp
088 75 543 54
[email protected]

Website for additional job details

https://www.academictransfer.com/338164/

Work Location(s)

Number of offers available

1

Company/Institute

UMC Utrecht

Country

Netherlands

City

Utrecht

Postal Code

3584CX

Street

Heidelberglaan 100

Geofield

Where to apply

Website

https://www.academictransfer.com/en/338164/technician-molecular-neuro-immunolog…

Contact

City

Utrecht

Website

http://www.umcutrecht.nl/

Street

Heidelberglaan 100

Postal Code

3584 CX

STATUS: EXPIRED