Research Technician: Development of in vitro Brain-muscle Connections

Updated: about 2 months ago
Deadline: 15 Mar 2021

Are you a motivated and experienced research technician who wants to support our research theme Complex Cell Systems at the Animal Science Department? We would like to get in contact with you.

As experienced technician your main task is to setup and differentiate iPSCs into muscle cells (i.e. skeletal & cardiac) and neuronal cells (i.e. neurons, glia cells, myelination). With these cells you will create functional in vitro innervated brain-muscle connections. At later stages you will also have a primary role in analysing and characterising the muscle innervation processes genetically, morphologically, and functionally. The ideal candidate would be able to culture and differentiate iPSCs or should be motivated to learn these novel skills and techniques. You will work in a team of research technicians and diverse scientists, supporting our research in developing complex cell models. Your work will also involve general lab duties and you may sometimes be asked to participate in teaching activities.

This position is part of the Complex Cell Systems investment theme of the Animal Science Department and you will be appointed at Wageningen University at Human and Animal Physiology, working in close collaboration with Host-Microbe Interactomics.

More about the project:
The widespread and increasing innovation and adoption of human complex cell system-based technologies is testament to their enormous potential as models for use in basic and translational research. Generation of innervated muscle tissues using induced pluripotent stem cells and ex vivo cultured cells is a pioneering field able to revolutionize the study of nerve and muscle physiology, development in humans but also animals. In combination with transcriptomic, metabolomic and proteomic profiling these complex cell systems promise to reveal crucial aspects of innervated muscle development, homeostasis and disease. This investment theme underpins the strong motivation within ASG to replace, reduce and refine animal experiments.

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