Postdoctoral researchers on a cell therapy for cornea regeneration at the MERLN Institute for... (# of pos: 2)

Updated: 2 months ago
Job Type: Temporary
Deadline: 28 Aug 2022

We seek two postdoctoral researchers to join our team developing cell therapies for ophthalmic diseases and conditions. The overall aim of this project is to bring a cell therapy for corneal endothelial disease into the clinic. We are working in a public–private partnership to optimize the cell biology in vitro, perform pre-clinical studies, and initiate a clinical study.

These positions are ideally suited to researchers with the ambition to work on a highly translational project. In addition to challenging scientific aims, we seek someone who wants to participate in the other elements of a successful cell therapy, such as designing (pre-)clinical trials, obtaining ethical approval, and monitoring intellectual property developments.

Briefly, our focus in this project is to develop a cell therapy for the corneal endothelium. Patients with corneal endothelial disease are currently treated by corneal transplantation. This is a largely successful procedure, but the increasing numbers of transplantations worldwide have created an urgent global tissue shortage. In order to tackle this scarcity, reliable sources of corneal endothelial cells are needed. These can be both primary cultures (expanded in large numbers from a single donor) or derived from pluripotent stem cells. We are working on therapies from both sources. Our position on the field can be read in a recent review (Catala et al. Prog Retin Eye Res 2022).

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