Postdoctoral researcher sought on a regenerative medicine cell therapy at the MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University

Postdoctoral researcher sought on a regenerative medicine cell therapy at the MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
Postdoctoral researcher sought on a regenerative medicine cell therapy at the MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University

Published	Deadline	Location
25 Apr	28 May	Maastricht

Job description

We seek a postdoctoral researcher to join our team developing (stem) cell therapies for ophthalmic diseases and conditions. The overall aim of this project is to bring a cell therapy for corneal endothelial disease into the clinic. We are working in a public–private partnership to optimize the cell biology and stem cell differentiation in vitro, perform pre-clinical studies, and initiate a clinical study.

This position is ideally suited to researchers with the experience and ambition to work on optimizing the biology of the cell therapy. This is a highly translational project so there will also be opportunities to participate in other elements, such as designing (pre-)clinical trials, obtaining ethical approval, and monitoring intellectual property developments if this is interesting to the successful candidate.

Briefly, our goal in this project is to develop a cell therapy for the corneal endothelium. Patients with corneal endothelial disease are currently treated by corneal transplantation. This is a largely successful procedure, but the increasing numbers of transplantations worldwide have created an urgent global tissue shortage. In order to tackle this scarcity, reliable sources of corneal endothelial cells are needed. These can be both primary cultures (expanded in large numbers from a single donor) or derived from pluripotent stem cells. We are working on therapies from both sources. Our position on the field can be read in a recent review (Catala et al. Prog Retin Eye Res 2022).

The candidate does not need to have specific experience in the cornea. Instead, expertise related to cell biology and directed differentiation of pluripotent stem cells for any cell type or in is welcome.

Specifications

• max. 38 hours per week
• €2960—€4670 per month
• Maastricht View on Google Maps

Maastricht University (UM)

Requirements

Applicant should possess a PhD in a relevant field (e.g., in the biomedical sciences, molecular biology, cell biology, or regenerative medicine). Candidates who have not yet completed their PhD are welcome to apply, but should be on track to finish prior to starting this position.

The ideal applicant has skills in molecular biology, especially techniques for manipulating cell fate in vitro, and in (stem) cell biology, especially the differentiation of pluripotent stem cells (iPSCs).

We are open to postdoctoral researchers with different levels of experience and can offer leadership opportunities on the project for those at a more senior level.

We are looking for creative thinkers who are prepared to take on highly challenging aims. The project will be very translational and will suit an ambitious candidate who likes a fast-paced environment with well-defined research aims. Excellent knowledge of scientific English for speaking, reading, and writing are required. Knowledge of Dutch is not required.

Conditions of employment

Fixed-term contract: 3–4 years (1+2 years or 1+3 years, respectively). The selected applicant will undergo an evaluation after 1 year, after which a decision is made to prolong the contract or not.

Salary is dependent on education and experience. The gross monthly salary is a minimum of €2,960 and a maximum of €4,670 in accordance with scale 10 of the collective labor agreement for Dutch Universities. An 8% holiday and an 8.3% year-end allowance is also provided.

In addition to good primary employment conditions, UM also offers an attractive package of secondary employment conditions.

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl  > About UM > Working at UM.

Employer
Maastricht University

Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 22,000 students and 5,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Science and Engineering, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.
For more information, visit www.maastrichtuniversity.nl .

Department
MERLN Institute for Technology-Inspired Regenerative Medicine | University Eye Clinic/Maastricht University Medical Center+

The successful candidate will have a cross-disciplinary supervision team comprising Dr Mor Dickman (University Eye Clinic Maastricht) and Dr Vanessa LaPointe (MERLN Institute for Technology-Inspired Regenerative Medicine). The research will be performed in the laboratory of Dr LaPointe at the MERLN Institute at Maastricht University (www.merlninstitute.com ). At MERLN, we are a collaborative, international, and interdisciplinary group with diverse expertise. We share newly renovated laboratory facilities with modern equipment. We have a long history as leaders in the field of tissue engineering and are particularly well-known for our orientation towards translational research.

The University Eye Clinic/Maastricht University Medical Center+ is one the largest academic departments of ophthalmology in Europe (www.oogheelkunde.mumc.nl ). The department is built on a strong foundation of medical education, research, and clinical care. Our clinicians provide care ranging from the routine to the very complex. Scientific work is focused on corneal diseases, cataract, and glaucoma, and is driven by a mission to understand and discover the basis for these conditions, and to develop treatments with a direct impact for patients and society.

Additional information

Applying from abroad?
MERLN houses researchers from across the globe who have successfully navigated the transition of moving to the Netherlands. Maastricht University is the most international university in the Netherlands. Thanks to its high-quality research and education as well as a strong focus on social engagement, Maastricht University has quickly built up a reputation as one of the best young universities in the world.

Maastricht, where we are located, is itself a warm and welcoming city. The city is known for its fine cuisine, excellent shops, and multicultural atmosphere. The founding city of the EU is an international hub with inhabitants from around the world. English is widely spoken, which has helped create a unique and vibrant international community. Thanks to Maastricht’s central position in Europe, it is only a short drive away from Belgium, Germany, France and the rest of the Netherlands. The city is family-friendly and possesses an international school and several excellent primary schools.

For those unfamiliar with the Dutch academic system, postdocs are paid a full-time salary and receive benefits along with an 8% holiday and 8.3% year-end bonus given annually. Candidates who need to relocate may be eligible for compensation. The terms of employment are set out in the Collective Labour Agreement of Dutch Universities (CAO-UNL), and local UM provisions also apply (see www.maastrichtuniversity.nl ).

Application timeline
Candidates can expect to hear from us within two weeks of the deadline for applications. Short video interviews will be scheduled for long-listed candidates. Those proceeding to the second interview round will be invited to attend either an in-person interview or a longer video call. Travel costs will be compensated.

For more information, please contact:
Dr. Vanessa LaPointe (v.lapointe@maastrichtuniversity.nl ).

To apply at this vacancy, press the button ‘apply now’ to see the application procedure.

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Application procedure

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The application form that can be downloaded here: https://surfdrive.surf.nl/files/index.php/s/OzeQGuycp8meWTp

A CV.

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Maastricht University is committed to promoting and nurturing a diverse and inclusive community. We believe that diversity in our staff and student population contributes to the quality of research and education at UM, and strive to enable this through inclusive policies and innovative projects led by teams of staff and students. We encourage you to apply for this position.