Postdoctoral Researcher Position in Mass Spectrometry Imaging
Postdoctoral Researcher Position in Mass Spectrometry Imaging
|10 Feb||26 Feb||Maastricht|
A fully funded postdoctoral position in the field of mass spectrometry imaging is available in
the research group of Dr. Sebastiaan Van Nuffel at the Maastricht MultiModal Molecular
Imaging (M4i) Institute, embedded in the Faculty of Health, Medicine and Life Sciences (FHML)
at Maastricht University.
Mass spectrometry imaging (MSI) is an exciting technique that is gaining popularity in the fields of biomedicine and medical diagnostics for its ability to chemically image tissues without the use of labels. MSI produces images of the locations of biochemical compounds that can help us understand and even better diagnose diseases such as cancer. Combining MSI with immunohistochemistry (MSI-IHC) is a new and rapidly growing technique that also enables targeted imaging of proteins at high spatial resolutions and can greatly improve the quality of the images; with much higher multiplexing than for example immunofluorescence microscopy . Unfortunately, typical MSI instruments are slow, limiting the throughput and field of view for MSI-IHC experiments. For example, it can take many hours or days to image 1 cm2 of tissue at a high spatial resolution. Last year, researchers at M4i developed fast mass microscopy (FMM), a technique that enables speeding up MSI more than 1,000 times — now experiments that would take a day can be done in a few minutes . The development of FMM poses challenges and opens opportunities for instrument and method development, validation, and optimization. One such opportunity is pairing FMM with IHC, which has not been done yet. With FMM-IHC, researchers could feasibly image hundreds to thousands of tissues in the time it takes to image a single tissue now while providing highly relevant biological information.
This postdoctoral position will focus on the methodological development of MSI-IHC for use in combination with FMM. In particular, the project aims to optimize the tissue sample preparation using metal-labelled antibodies, the instrument parameters for a PHI nanoTOF II Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) instrument as well as data analysis procedures . This position will work within a team of dedicated researchers at the M4i Institute and collaborate with partners at Penn State and ETH Zürich. At M4i, you will have a partner postdoctoral researcher who is dedicated to the further improvement of the FMM instrumentation itself for FMM-IHC. In the second half of the project, you and your partner postdoctoral researcher will collaborate to conduct a large screening of many biological tissue samples to demonstrate and validate the combined FMM-IHC technology. You will present your findings at leading international conferences at least once a year and will publish in peer review journals with open access unlocked for all publications.
The postdoctoral position will be supervised by Dr. Sebastiaan Van Nuffel and co-supervised by Dr. Ian Anthony. The anticipated start date is June 1, 2023, but reasonable accommodations can be made for the right candidate. The funding for this position is provided by the Chan Zuckerberg Initiative (CZI) under the project title “Fast Mass Spectrometry Imaging for Immunohistochemistry”.
 Bodenmiller, B. Cell Systems 2016, 2, 225. 10.1016/j.cels.2016.03.008
 Körber, A. et al., Anal Chem. 2022, 94, 14652-8. 10.1021/acs.analchem.2c02870
 Van Nuffel, S. et al., Anal. Chem. 2020, 92, 12079. 10.1021/acs.analchem.0c02815
- max. 38 hours per week
- €2960—€4670 per month
- Maastricht View on Google Maps
Maastricht University (UM)
Skills and qualifications
- A PhD degree in Chemistry, Physics, Materials Science, Chemical Engineering, Biochemistry or a related subject;
- Lab experience with mass spectrometry imaging (MSI);
- A publishing record with at least one first-author publication;
- Proficiency in English (C1 or higher);
- Capacity to quickly acquire new knowledge and master new skills;
- Interest in both hands-on research activities and data analysis;
- Ability to work independently and as a member of a research team;
- Problem solving skills and creativity. Preferred (if you have a couple of these, you are more likely to succeed):
Preferred (if you have a couple of these, you are more likely to succeed):
- Lab experience with Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS);
- Lab experience with histological techniques such as immunohistochemistry (IHC);
- Lab experience with optical microscopy techniques;
- In-depth knowledge of basic statistics and image data processing.
Desired (not vital, but highly appreciated):
- Programming skills.
Conditions of employment
One year with funding for extension up to one more year. The first year will be a probation period, after a positive assessment the position can be extended for nine months on the project. The pay is commensurate with experience and corresponds to salary scale 10 (2,960 to 4,670 EUR per month).
On top of this, there is an 8% holiday and an 8.3% year-end allowance.
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl > About UM > Working at UM .
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 20,000 students and 4,700 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Science and Engineering, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience. For more information, please visit www.maastrichtuniversity.nl.
For more information regarding this vacancy, you can contact: Dr. Sebastiaan Van Nuffel (firstname.lastname@example.org )
Working at Maastricht University
Maastricht University distinguishes itself with its innovative education model, international character and multidisciplinary approach to research and education.
Apply via postal mail
Apply via postal mail
Don't forget to mention AcademicTransfer and the job number: AT2023.79 in your letter.
Back to the vacancy
Interested candidates are invited to submit a cover letter, an up-to-date CV, copies of their tertiary degrees and the contact details of at least two references. Candidates should submit an application by 26 February 2023, through Academic Transfer: email@example.com. Please mention also the vacancy number/job number (AT2023.79) and the project name in your application. Maastricht University is committed to nurturing an inclusive culture and a welcoming atmosphere. This inclusiveness strategy has resulted in a very diverse representation of nationalities and cultures. We strongly believe that diversity (including, but not limited to nationality, age and gender) of the staff and student population will increase the quality of UM education & research. Fostering diversity and inclusivity creates an academic community where individual talents thrive, and values and differences are cherished. We strongly encourage you to apply if you are qualified for this position
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