Postdoctoral researcher Nanoscopy of Ice-Binding Proteins

Eindhoven University of Technology, Netherlands

Updated: almost 2 years ago
Deadline: 05 Jun 2022

Position

(Post-doctoral) Researcher


Department(s)

Chemical Engineering and Chemistry


Reference number

V37.5602


Job description
  • Can’t wait to do single molecule tracking on ice-cold and crystal-clear interfaces?
  • Are you fascinated by ice crystal growth and antifreeze proteins?
  • Do you master super-resolution microscopy?
  • Are you passionate about science?
  • Do you want to work in a multidisciplinary team?

    • JobDescription

    Ice-binding proteins (IBPs) offer protection against freezing to sustain life at subzero temperatures in ice-laden environments. How IBPs work exactly is not yet known, but it is clear that their activity is closely related to the way in which IBPs interact with ice. Recently, we adopted sub-zero nanoscopy to study for the first time the interfacial dynamics of ice-bound IBPs at the single molecule level (see preprint for more information). These pioneering experiments offer unprecedented insight in the structure-activity relations of IBPs. In this project you will use subzero nanoscopy to study the interaction with ice of biological IBPs and (de novo) designed ice-binders at the single molecule level aiming to better understand how biological and (bio)synthetic antifreezes block ice growth, shape ice crystals, inhibit ice recrystallization and control ice nucleation. You will work in close collaboration with other group members, who design and prepare biological and (bio)synthetic IBPs and explore their application potential in cardiomyocyte preservation. Our aim is to unravel how biological and engineered ice-binders function and to customize these cryoprotectants for biomedical and other applications.


    Job requirements
    • PhD in biophysics, Molecular (Life) Sciences, Biophysical Chemistry, Bionanoscience or related area.
    • Strong qualifications or experience with quantitative nanoscopy, single molecule tracking, quantitative data analysis.
    • Passionate about protein biophysics and/or soft matter science, microscopy.
    • Experience with (computer-aided) protein engineering, single protein biophysics; knowledge of crystallization and microfluidics is preferred.
    • Ability to conduct high quality academic research, demonstrated by an outstanding PhD thesis and publications in peer-reviewed journals.
    • Strong motivation to do excellent, original, fundamental research.
    • Excellent mastering of the English language, good communication and leadership skills. Note that there is no Dutch language requirement.
    • Independent and goal-oriented scientist. Team player and able to work in a dynamic, interdisciplinary, and international context.

    Conditions of employment
    • A meaningful job in a dynamic and ambitious university with the possibility to present your work at international conferences.
    • A full-time employment for 2 years.
    • You will have free access to high-quality training programs on general skills, didactics and topics related to research and valorization.
    • A gross monthly salary and benefits in accordance with the Collective Labor Agreement for Dutch Universities.
    • Additionally, an annual holiday allowance of 8% of the yearly salary, plus a year-end allowance of 8.3% of the annual salary.
    • A broad package of fringe benefits (including an excellent technical infrastructure, moving expenses, and savings schemes).
    • Family-friendly initiatives are in place, such as an international spouse program, and excellent on-campus children day care and sports facilities.

    Information and application

    More information

    Do you recognize yourself in this profile and would you like to know more? Please contact
    prof.dr.ir. Ilja Voets, i.voets[at]tue.nl or +31 40 247 5303

    For information about terms of employment, click here or contact Leo van Houten,
    l.v.houten[at]tue.nl or +31 40 247 8269

    Please visit www.tue.nl/jobs to find out more about working at TU/e!

    Application

    We invite you to submit a complete application by using the 'apply now'-button on this page.
    The application should include a:

    • Cover letter in which you describe your motivation and qualifications for the position.
    • Curriculum vitae, including a list of your publications and the contact information of three references.
    • A letter of recommendation from one or more of your references.
    • List of five self-selected ‘best publications’ with motivation for their selection.

    We look forward to your application and will screen your application as soon as possible. The vacancy will remain open until the position is filled.

    We do not respond to applications that are sent to us in a different way.

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