POSTDOCTORAL RESEARCHER, MODELING GENE DISRUPTIONS IN HUMAN NEURONS

Updated: 3 months ago
Deadline: 09 Jan 2024

29 Nov 2023
Job Information
Organisation/Company

Max Planck Institute for Psycholinguistics
Research Field

Physics
Medical sciences
Researcher Profile

Recognised Researcher (R2)
Country

Netherlands
Application Deadline

9 Jan 2024 - 22:59 (UTC)
Type of Contract

Temporary
Job Status

Not Applicable
Hours Per Week

39.0
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We have identified multiple rare gene disruptions that cause speech and language disorders in human neurodevelopmental syndromes. You will lead specific projects within a broader ongoing research programme that investigates the neurobiological consequences of such gene disruptions (in FOXP1/2/4, CHD3SETBP1 among other genes) in human cell models grown in the lab.

This programme adopts the latest human cell-culture techniques (stem-cell derived 2D and 3D neuronal models), CRISPR/Cas-based gene editing, single-cell and spatial transcriptomics, and other state-of-the-art methods of the field.

You will carry out your work in our custom-built molecular biology laboratories at the Max Planck Institute, which has its own cell-culture facilities, an advanced microfluidics system for high-throughput single-cell analyses, and dedicated histology and microscopy suites, including a confocal microscope with live cell-imaging capabilities, as well as a slide scanner for high-throughput imaging. These resources are complemented by bioinformatic expertise within the department, excellent in-house infrastructure for data analysis supported by a central technical group, and close collaborative links with the Human Genetics department of Radboudumc, on the same campus, as well as clinical colleagues around the world. You will be involved in supervising junior scientists, including students and research assistants, and writing up findings for publication, and will have opportunities to present your work at (inter)national workshops and conferences.


Requirements
Specific Requirements
  • You are a research scientist who holds, or shortly expects to obtain, a PhD in a field that has given you extensive wet-laboratory experience, including hands-on work with human stem cell-culture models.
  • Previous experience with generating and characterizing stem-cell derived 2D neuronal cultures or brain spheroids/organoids is necessary.
  • Expertise in a range of molecular and cell biological methods is also essential.
  • Familiarity or experience with gene-editing (e.g. via CRISPR/Cas), single-cell transcriptomics/epigenetics (and related bioinformatic analyses), and/or assays of neuronal properties (e.g. differentiation and maturation, morphology, activity) will be an advantage.
  • You have a critical and careful approach to laboratory work and record keeping, and you strive for robustness and reproducibility of results.
  • You are organized and adept in communicating project plans and outcomes to others, in both spoken and written form.
  • You are interested in working together with researchers from a wide range of backgrounds.

Additional Information
Benefits
  • This position is available from February 2024, but start date is negotiable. The term of appointment is full-time (39 hours per week) for 3 years.
  • The salary is according to the German TVöD (Tarifvertrag für den öffentlichen Dienst) and is classified in salary group E13, between EUR 4,187.45 and EUR 5,392.57 per month, depending on the experience of the applicant (including 8% holiday bonus), based on full-time employment.
  • Research staff have access to cutting-edge research and training facilities and technical infrastructure, and to funding for conferences/travel.

Selection process

To apply, please submit via the application button:

  •   A 1-2 page statement of interest, including motivation behind applying and specific explanation of how your skills fit the requirements of the position.
  •   CV including research achievements and list of outputs such as publications, preprints and presentations.
  •   Names, email addresses and contact numbers of at least two referees who would be willing to provide letters of recommendation.
  • The closing date for applications is 9 January 2024.

     


    Additional comments

    To apply, please submit via the application button:

  •   A 1-2 page statement of interest, including motivation behind applying and specific explanation of how your skills fit the requirements of the position.
  •   CV including research achievements and list of outputs such as publications, preprints and presentations.
  •   Names, email addresses and contact numbers of at least two referees who would be willing to provide letters of recommendation.
  • The closing date for applications is 9 January 2024.

    For enquiries, please contact the secretariat at the Language & Genetics Department (E-mail: [email protected] ).

    Example publications

    Den Hoed J, Fisher SE. Genetic pathways involved in human speech disorders. Curr Opin Genet Dev 65:103-111. https://doi.org/10.1016/j.gde.2020.05.012

    Wong MMK et al. SETBP1 variants outside the degron disrupt DNA-binding and transcription independent of protein abundance to cause a heterogeneous neurodevelopmental disorder. medRxiv. https://doi.org/10.1101/2022.03.04.22271462

    Snijders Blok L et al. CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun 9: 4619. https://doi.org/10.1038/s41467-018-06014-6

     


    Website for additional job details

    https://www.academictransfer.com/335055/

    Work Location(s)
    Number of offers available
    1
    Company/Institute
    Max Planck Institute for Psycholinguistics
    Country
    Netherlands
    City
    Nijmegen
    Postal Code
    6525 XD
    Street
    Wundtlaan 1

    Where to apply
    Website

    https://www.academictransfer.com/en/335055/postdoctoral-researcher-modeling-gen…

    Contact
    City

    Nijmegen
    Website

    http://www.mpi.nl/
    Street

    Wundtlaan 1
    Postal Code

    6525 XD

    STATUS: EXPIRED

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