Postdoctoral researcher Engineered Ice-Binders

Eindhoven University of Technology (TU/e), Netherlands

Updated: over 1 year ago
Job Type: Temporary
Deadline: 02 Dec 2022

  • Are you interested in (de novo) protein design?
  • Are you fascinated by ice crystal growth?
  • Do you want to combine computational tools for de novo protein design with experimental studies on your designer proteins?
  • Would you like to know more about antifreeze proteins and cryobiology?
  • Are you passionate about research?
  • Do you want to work in a multidisciplinary team?
  • Do you want to work in a multidisciplinary team?

    • JobDescription

    Ice-binding proteins (IBPs) protect against freeze damage in polar regions by keeping the nucleation and growth of ice crystals in check. How this works exactly is not yet known. This is because we currently lack designer ice-binders to unravel and utilize the structure-function relations underlying activity. In this project you will combine computational tools for protein engineering (de novo protein design, folding) with biochemical and structural biology techniques (protein expression, structure elucidation, activity assays) to bridge this knowledge gap. You will engineer IBPs de novo. You will express and study promising designs to elucidate the relation between IBP structure, composition and function. Through collaborations within the group and (inter)nationally, you will study how your designer IBPs with optimized and customized activity interact with ice and may be exploited for cardiac regenerative medicine.


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