Are you eager to work on regenerating functional articular cartilage from organoids grown from iPSCs?
This vacancy is posted as part of RegMedXB, which stands for “Regenerative Medicine Crossing Borders”. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. The RegMedXB Cardiac Moonshot program aims at developing innovative strategies to regenerate the tissues of the heart, including the myocardium, heart valves and blood vessels.
The current project concentrates on developing cartilage organoids from iPSCs in suspension culture and their use in hyaline neo-cartilage formation. For this you will investigate the mechanobiological induction and culture conditions of induced chondrocytes and organoid self-assembly using advanced culture platforms and characterization assays. The produced organoids will be combined with innovative relaxing hydrogels and in a bi-directional loaded ex vivo osteochondral culture bioreactor to investigate their mechanism for formation into neo-cartilage.
If you are fascinated by the engineering aspects of regenerative medicine and eager to develop innovate models and strategies that will advance cartilage regeneration, we invite you to join us in this challenge. You will collaborate intensively with our partners in the RegMed-XB OA Moonshot consortium, in particular with the University Medical Centers in Leiden and Utrecht, as well as commercial partners, on iPSC induction, in vitro organoid self-assembly, and ex vivo load stimulated tissue engineering.
- A PhD degree in biomedical engineering, biomedical science, mechanical engineering, regenerative medicine, or a comparable domain
- Ability to conduct high quality academic research, demonstrated for instance by relevant publications in the area of research
- Background in biomaterials and mechanobiology with affinity for medical applications
- Experience with tissue culture and tissue characterization
- Be a team player and able to contribute to and initiate cross-disciplinary collaborations
- Excellent mastering of the English language, good written and oral communication skills. Note that there is no Dutch language requirement.
- Result-driven and proactive attitude
Conditions of employment
- A meaningful job in a dynamic and ambitious university with the possibility to present your work at international conferences.
- A full-time employment for 2 years, starting with a one-year contract.
- You will have free access to high-quality training programs for research and valorization, professional development courses for PhD students, and didactical courses of the TEACH training program.
- A gross monthly salary and benefits in accordance with the Collective Labor Agreement for Dutch Universities.
- A broad package of fringe benefits (including an excellent technical infrastructure, moving expenses, and savings schemes).
- Family-friendly initiatives are in place, such as an international spouse program, and excellent on-campus children day care and sports facilities.
Information and application
Do you recognize yourself in this profile and would you like to know more? Please contact
prof.dr. Keita Ito, k.ito[at]tue.nl.
Information about the RegMedXB program can be found on: www.regmedxb.com
Information about the Biomedical Engineering department can be found at: https://www.tue.nl/en/our-university/departments/biomedical-engineering/
Information about the Orthopaedic Biomechanics group can be found at: https://www.tue.nl/en/research/research-groups/orthopaedic-biomechanics/
For information about terms of employment, please contact Sascha Sanchez, HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or HRServices.Gemini[at]tue.nl
Please visit www.tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'apply now'-button on this page.
The application should include a:
- Cover letter in which you describe your motivation and qualifications for the position.
- Curriculum vitae, including a list of your publications and the contact information of
- List of five self-selected ‘best publications’.
We look forward to your application and will screen it as soon as we have received it.
Screening will continue until the position has been filled.
About Eindhoven University of Technology (TU/e)
TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
The research will be mainly conducted within the Soft Tissue Engineering and Mechanobiology (STEM) group in the Department of Biomedical Engineering.
The OPB group, headed by prof.dr. K. Ito, combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. They cover diverse topics in bone, intervertebral disc and tendons/ligaments, as well as articular cartilage. The group is well known for their multidisciplinary approach combining tissue mechanics, mechanobiology, tissue and biomaterial mechanics, ex vivo bioreactor platforms and computational models to optimize tissue conditions for regenerative engineering. The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.
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