Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium Tuberculosis. Even though TB is curable, about one and a half million people succumb to it every year. Current treatments are long and with side effects: the need for new antibiotics and vaccines is obvious.
We aim to understand how gene products or proteins work within their cellular environment in health and disease. Our institute houses a state of the art cryo-Light Microscopy/Electron Microscopy correlative workflow from cellular localization, milling with focused ion beam (FIB-SEM), down to cryo-electron tomography, subvolume averaging and image processing to study how these nano-machines work under native conditions.
We seek a talented Postdoctoral candidate to join our interdisciplinary team. Our biology research focuses on unraveling, controlling and tempering the pathogenicity of Mycobacterium tuberculosis at a molecular level. The applicant will apply in situ structural biology to understand these nano-machines within its native context of the infected cell. The important work in biochemistry and single particle analysis performed in our group will support the candidate´s project. The candidate will work within a team of academic investigators and (industrial) engineers to research and develop a next generation Vitrojet device for optimal vitrification of cells together with some companies like our startup www.cryosol-world.com .
Recent relevant publications from our lab:
Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography.
Berger C, Ravelli RBG, López-Iglesias C, Kudryashev M, Diepold A, Peters PJ.
J Struct Biol. 2021 Mar;213(1):107701.
Endocytosed nanogold fiducials for improved in-situ cryo-electron tomography tilt-series alignment.
Berger C, Ravelli RBG, López-Iglesias C, Peters PJ.
J Struct Biol. 2021 Mar;213(1):107698.
Cryo-EM structures from sub-nl volumes using pin-printing and jet vitrification.
Ravelli RBG, Nijpels FJT, Henderikx RJM, Weissenberger G, Thewessem S, Gijsbers A, Beulen BWAMM, López-Iglesias C, Peters PJ.
Nat Commun. 2020 May 22;11(1):2563.
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