A postdoc position is available at the department of Oncogenomics, Amsterdam UMC, to study mechanisms of therapy resistance and development of relapse in the pediatric tumor neuroblastoma.
About your role
We have established that neuroblastoma is composed of two phenotypically divergent types of tumor cells (van Groningen et al., Nat Genet., 2017. PMID 28650485). An undifferentiated, mesenchymal tumor cell-type is resistant to therapy and we hypothesize that these cells are responsible for the outgrowth of relapse tumors. In a KWF-funded project, we aim to rigorously test this model using genetic lineage tracing of the divergent neuroblastoma cell types in relapse models of human neuroblastoma.
You will be responsible for the development and validation of lineage-tracer cell lines, which includes the molecular cloning of targeting vectors and CRISPR/Cas9-mediated targeted integration in neuroblastoma cell lines. These lineage-tracing lines will be used to identify the cellular origin of neuroblastoma relapse in xenograft models. You will analyze lineage-traced cells using single-cell RNA sequencing to study transcriptional plasticity during the development of relapse.
The project
Research in our laboratory is focused on the phenotypic heterogeneity and plasticity of cancer cell types to unravel the fundamental principles of neuroblastoma biology. We aim to identify the cell-of-origin of neuroblastoma relapse and understand the plasticity of cellular states in tumor progression and relapse development. The outcome of these studies will guide the development of new combination therapy to combat neuroblastoma.
Similar Positions
-
Postdoctoral Scholarship Researcher In Cancer Research Focusing On Intratumor Heterogeneity And Phenotypic Plasticity, Karolinska Institutet, Sweden, 1 day ago
Do you want to contribute to top quality medical research? The successful candidate will work on childhood neuroblastoma and paraganglioma in the research group headed by Susanne Schlisio : The r...
-
Postdoc Position In Natural Killer Cell Biology And Cell Therapy , University of Oslo, Norway, 1 day ago
8th May 2024 Languages English English English Postdoc position in natural killer cell biology and cell therapy Apply for this job See advertisement The Precision Immunotherapy Alliance (PRIMA) PR...
-
Postdoctoral Position In Bacterial Cell Wall Biology And Genetics , Umeå University, Sweden, about 12 hours ago
Umeå University is one of Sweden’s largest higher education institutions with over 37,000 students and about 4,700 employees. The University offers a diversity of high-quality education and world-...
-
Postdoctoral Fellow Car Nk Cells, City of Hope, United States, 1 day ago
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope ,where we're changing lives and making a real difference in the fight against cancer, diabetes, and ...
-
Postdoc Position In Natural Killer Cell Biology And Cell Therapy, University of Oslo, Norway, about 23 hours ago
powered by: Cookie Information Nettsiden bruker cookies Vi ønsker at du skal være trygg når du bruker dette nettstedet. Vi benytter cookies for å sikre at du får en best mulig brukeropplevelse og ...
-
Research Assistant To Karolinska Institutet, Karolinska Institutet, Sweden, 7 days ago
Do you want to contribute to top quality medical research? We are seeking a motivated research assistant to help us improve drug combination therapies for pediatric cancer, using advanced methods ...