Postdoc Structural Biology of the Neuronal Synapse

Postdoc Structural Biology of the Neuronal Synapse
Postdoc Structural Biology of the Neuronal Synapse

Published	Deadline	Location
24 Mar	1 May	Delft

Do you want to identify the molecular mechanisms of synapse formation?  Are you interested in neuroscience at the nanoscale?
Job description

A 3-year postdoc position is available in the research group of Dimphna Meijer, Department of Bionanoscience, Delft University of Technology, the Netherlands.

 

The long-term goal of our research is to understand synapse assembly and disassembly at the molecular level, during health and disease. We address questions such as: What is the underlying structural basis of synapse formation? What happens at the nanoscale in a diseased brain? We have recently determined several cryo-EM structures of synaptic cell adhesion molecules that together reveal part of a molecular recognition code. We are now aiming to understand molecular recognition and synapse formation in a cellular context using a combination of protein biochemistry & biophysics, structural biology, and mammalian cell biology approaches.

 

The successful applicant will be the driver of a new project concerning detailed structural characterization of synapse assembly with a bottom-up approach. State-of-the-art equipment, including high-end light and (cryo-)electron microscopes, as well as advanced mammalian cell culture facilities are available in our department. 

 

We are an international, growing team of multidisciplinary scientists. We aim for a high-impact, supportive environment, where talented people work together to solve neurobiological questions. See also our group website www.dimphnameijerlab.org.

 

Specifications

• 36—40 hours per week
• €2960—€4670 per month
• Delft View on Google Maps

Delft University of Technology (TU Delft)

Requirements

We are looking for a highly motivated and goal-oriented postdoctoral researcher with a Ph.D. degree in structural biology, single molecular biophysics, or related field. The ideal candidate has a strong background in structural biology and is interested in applying cryo-electron microscopy and cryoe-electron tomography to neurobiological questions. Cryo-EM/Cryo-ET experience is a plus but not required. The candidate should be fluent in English and motivated to work in an ambitious and collaborative research team.

 

Conditions of employment

Fixed-term contract: 3 years.

We offer an appointment as a postdoc for a period of 3 years. Remuneration will be according to the scales set by the Collective Labour Agreement for Dutch Universities (CAO NU), and will range from € 2.960,- per month to € 4.670,- per month (gross amounts, in case of fulltime employment). Applicants should have the right to work in the Netherlands for the duration of the contract. Fulltime is considered to be 38 hours per week.

 

Employer
Delft University of Technology

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct ). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale.

Challenge. Change. Impact! 

 

Department
Department

Faculty of Applied Sciences

With more than 1,000 employees, including 135 pioneering principal investigators, as well as a population of about 3,400 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we train students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers and science communicators.

Click here to go to the website of the Faculty of Applied Sciences.

 

Department Bionanoscience

The Department of Bionanoscience focuses on the fundamental understanding of biological processes, from the level of single molecules to the full complexity of living cells. This research provides fascinating insight in the molecular mechanisms that lead to cellular function. Furthermore it enables the in vitro bottom-up construction of cellular machinery and it impacts applications ranging from biomolecular diagnostics to novel antibiotics and targeted nanomedicine. The department features a strongly multidisciplinary and international team of scientists, whose research areas include single-molecule biophysics, synthetic biology, as well as (quantitative) cell biology.

 

Additional information

For more information about this vacancy, please contact Dr. Dimphna Meijer, Principal Investigator, e-mail: [email protected]    

 

 

Working at TU Delft

Join the oldest and largest technical university in the Netherlands. Work on clever solutions for worldwide challenges, to change the world and make an impact. Ready to bring your energy to our research?

Challenge, change, impact!

Apply for this job
Apply for this job

This application process is managed by the employer (Delft University of Technology (TU Delft)). Please contact the employer for questions regarding your application.

Apply for this job via the employer's website
Thank you for applying

Please contact the employer for questions regarding your application.

Tip: save this job as favorite in your AcademicTransfer account. This gives you an immediate overview and makes it easy to find the job later on. No account yet? Create it now and take advantage of other useful functionalities too!

Back to the vacancy
Application procedure

Are you interested in this vacancy? Please apply before 01 May 2023 via the application button and upload the following information in English (pdf format only):

Letter of motivation (generic letters will be disregarded).

Detailed CV.

Three names of potential references.