Postdoc Structural Biology of the Neuronal Synapse

Updated: 4 months ago
Deadline: 15 Jun 2023

13 May 2023
Job Information

Delft University of Technology (TU Delft)
Research Field

Researcher Profile

Recognised Researcher (R2)

Application Deadline

15 Jun 2023 - 21:59 (UTC)
Type of Contract

Job Status

Not Applicable
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?


Offer Description

Neurodegenerative diseases like Parkinson’s, Alzheimer’s and other dementia's severely affect the lives of patients and their loved ones. To develop future treatments, gaining an in-depth understanding of (dys)functional synapses is crucial. As a postdoc at TU Delft you will take the lead in the development of a simple biophysical model of synapses at nanoscale. This bottom-up model will help identify the mechanisms of synapse formation in healthy and diseased neurons. Would you like to conduct fundamental research at the interface between biology, chemistry and biophysics?

To develop the synapse model using a bottom-up approach, you will reconstruct macro-molecular protein complexes in situ, study them with our state-of-the-art light and cryo-electron microscopes, and reveal novel structure-function relationships. You will also tackle the technical challenges related to the sample prep and cryo-EM/cryo-ET. In this project you will work closely with neurologists of Erasmus Medical Centre in Rotterdam, who will provide us with clinical data that you can embed in your model. Within the scope of our roadmap, you will be encouraged to develop your own vision to set up your own line of research for your future career step.

You will be joining the Structural Neurobiology team, an international group of academic students and staff. Our team fosters an open, collaborative, and reflective environment, where we embrace different perspectives in order to ensure high-quality research. We share a common goal to advance the field of neuroscience by overcoming scientific and technical challenges. As part of this role, you will have the opportunity to supervise and mentor PhD, Master’s and Bachelor’s students, while receiving support and training to further develop your own academic career. See for more information on our group: .

Specific Requirements

You have a background in structural biology and share our fascination with molecular interactions that underlie life. Harnessing your communication skills, you persuade, motivate and mentor individuals from diverse backgrounds, ranging from students to neurologists, to achieve meaningful results. You have a keen eye for details, yet maintain focus on the big picture. Recognising the importance of collaboration, you are a true teamplayer. While, as an independent researcher, you possess the skills necessary to develop your own research project to completion.

You also have:

  • A PhD in structural biology, single molecular biophysics, or a related subject.
  • Experience of, or a keen interest in Cryo-EM/Cryo-ET.
  • A good command of English, as you will be working in an international, ambitious and collaborative environment.

Additional Information

We offer an appointment as a postdoc for a period of 3 years. Remuneration will be according to the scales set by the Collective Labour Agreement for Dutch Universities (CAO NU), and will range from € 2.960,- per month to € 4.670,- per month (gross amounts, in case of fulltime employment). Applicants should have the right to work in the Netherlands for the duration of the contract. Fulltime is considered to be 38 hours per week.

Selection process

Are you interested in this vacancy? Please apply before 15th of June 2023 via the application button and upload the following information in English (pdf format only):

  • Letter of motivation (generic letters will be disregarded),
  • Detailed CV with publication list,
  • Three names of potential references.

  • Additional comments

    For more information about this vacancy, please contact Dr. Dimphna Meijer, Principal Investigator, e-mail:

    Website for additional job details

    Work Location(s)
    Number of offers available
    Delft University of Technology
    Postal Code
    2628 CD
    Mekelweg 2

    Where to apply



    Mekelweg 2
    Postal Code

    2628 CD

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