The group of cell-matrix adhesion (Group Arnoud Sonnenberg) and the Translational Gastrointestinal Oncology (TGO) group (Group Gerrit Meijer) at the Netherlands Cancer Institute collaborate in colorectal cancer (CRC) research with emphasis on understanding the role of adhesion molecules in the progression from adenoma to carcinoma.
In the context of a joint Dutch Cancer Society (KWF) project entitled “Analysis of the role of PEAK1, an integrin-associated pseudokinase, in the initiation and progression of colorectal carcinomas ”, we are recruiting a full-time cancer biologist/ biochemist to dissect the functional role of PEAK1 in in vitro and in vivo model systems.
PEAK1 is a pseudokinase that serves as a scaffolding protein to coordinate signaling by integrins and receptor tyrosine kinases in the regulation of cell proliferation and cytoskeletal remodeling. The protein is dynamically phosphorylated at several tyrosine residues during colon carcinoma progression, which may allow transient binding of PEAK1 to adaptor molecules. In this project we aim to study the involvement of PEAK1 and the site-specific tyrosine phosphorylation at one tyrosine residue that is found primarily in adenomas, in the progression of colorectal adenomas to carcinomas.
Postdoc On Proteomics Of The 14 3 3 Interactome And The P53/14 3 3 Complex, Eindhoven University of Technology (TU/e), Netherlands, 10 days ago
The adapter protein 14-3-3 acts as a 'hub' by interacting with several hundred partner proteins in human cells. These 14-3-3 PPIs are implicated in a number of diseases ranging from cancer and neu...
Ph D / Post Doc In Biophysics , Technical University of Munich, Germany, about 9 hours ago
03.05.2021, Wissenschaftliches Personal Living cells rely on the ability of the cytoskeleton to continuously form and destroy diverse structures, which is strongly coupled to the adhesion processe...
Postdoctoral Fellow, EMBL, Worldwide, 18 minutes ago
The Petsalaki Group uses data-driven and network-based approaches to understand the principles underpinning context-specific cell signalling. We are an interdisciplinary team using computational ...
Scientific Research Assistent, Institutul de Biochimie al Academiei Romane Bucuresti, Romania, 19 days ago
Biology, Chemistry, Pharmacy, Medicine, Biotechnology or Chemical Engineering-BS or MS degree; Basic knowledge of biochemistry, molecular and cellular biology Good oral and communication skills En...
Postdoc On Proteomics Of The 14 3 3 Interactome And The P53/14 3 3 Complex, Eindhoven University of Technology, Netherlands, about 14 hours ago
Position (Post-doctoral) Researcher Department(s) Biomedical Engineering Reference number V50.4968 Job description The adapter protein 14-3-3 acts as a “hub” by interacting with several hundred pa...
Postdoctoral Fellow At The Ulb Center For Diabetes Research (# Of Pos: 2), Université Libre de Bruxelles (ULB), Belgium, 22 days ago
One postdoctoral fellow position is available at the ULB Center for Diabetes Research, Brussels, Belgium (https://www.ucdr.be/ ). We are looking for a highly motivated researcher to join the lab o...