Postdoc - Cell Biology/Translational Gastrointestinal Oncology

Updated: about 2 months ago
Deadline: 21 Apr 2021

The group of cell-matrix adhesion (Group Arnoud Sonnenberg) and the Translational Gastrointestinal Oncology (TGO) group (Group Gerrit Meijer) at the Netherlands Cancer Institute collaborate in colorectal cancer (CRC) research with emphasis on understanding the role of adhesion molecules in the progression from adenoma to carcinoma.
In the context of a joint Dutch Cancer Society (KWF) project entitled “Analysis of the role of PEAK1, an integrin-associated pseudokinase, in the initiation and progression of colorectal carcinomas ”, we are recruiting a full-time cancer biologist/ biochemist to dissect the functional role of PEAK1 in in vitro and in vivo model systems.

Project background:
PEAK1 is a pseudokinase that serves as a scaffolding protein to coordinate signaling by integrins and receptor tyrosine kinases in the regulation of cell proliferation and cytoskeletal remodeling. The protein is dynamically phosphorylated at several tyrosine residues during colon carcinoma progression, which may allow transient binding of PEAK1 to adaptor molecules. In this project we aim to study the involvement of PEAK1 and the site-specific tyrosine phosphorylation at one tyrosine residue that is found primarily in adenomas, in the progression of colorectal adenomas to carcinomas. 

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