Most cancer patients die from malignant metastases, or because they have become insensitive to chemotherapy. In this multidisciplinary project, which will be carried out in collaboration with ErasmusMC and TuDelft, we aim to repurpose existing drugs to selectively change the behavior of aggressive cancer cells to non-invasive and therapy-sensitive cancer cells or change them into benign fat cells. This will be accomplished by using a library of over 5685 chemical compounds/drugs. The initial results of the screenings look promising. You will use cell biology, biochemistry and in vivo cancer models. In collaboration with colleagues, you will also test the effect of selected compounds/drugs on circulating tumor cells from breast and lung cancer patients.
In short
· You will be part of our research group focused on studying signal transduction processes in human cells
· You will study the important role of TGF-beta in the epithelial to mesenchymal transition of cancer cells and investigate how we can use existing drugs to counteract the malignant behavior of mesenchymal cancer cells
· You have a PhD degree in cell biology/biochemistry or simila
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