Post-Doc/Bioinformatician liquid biopsy

2 May 2024
Job Information

Organisation/Company

Amsterdam UMC

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)

Country

Netherlands

Application Deadline

16 May 2024 - 21:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The department of Pathology mission is to inform clinicians for the optimal available treatment outcome while avoiding unnecessary side-effects and over-treatment. The vision of the Exosomes Research Group is to develop advanced molecular techniques for minimially inavasive (blood-based) diagnostics. We foresee that blood test will become increasingly important for future (early) cancer diagnosis and evaluation (monitoring) and prediction of treatment response.

In multidisciplinary teams our main aim to personalize the treatment of cancer patients. The Liquid Biopsy Center of the Cancer Center Amsterdam, is a unique initiative to collect blood samples and clinical data of thousands of cancer patients. The ERG develops innovative sequencing protocols and computational tools to analyze cell-free RNA and DNA in the blood of patients. In this project we aim, together with lab-on a chip and gene-editing experts from the Universities of Twente and Wageningen, to detect RNA biomarkers with CRISPR-Cas13. This technology is ultra-sensative and may revolutionize ‘point of care ‘cancer diagnostics.

You will work with state-of-the-art sequencing technologies to profile blood samples in search of molecular signatures that predict outcome. These blood samples will be collected in national and international clinical trials. Specifically, you will look for advances in cell-free DNA and cell-free RNA computational analysis with a focus on circulating extracellular vesicles (EV) as nulecic acid sopurce as these nanoparticles are used by tumor and immune cells for inter- and inter-tumor communication. State of the art cfDNA analysis includes fragmentomics and methylation, while EV-RNA analysis will be performed with deconvolution to assess EV origin, composition and dynamics.

Requirements
Specific Requirements

We are looking for an enthusiastic researcher who has recently received or will soon receive a PhD in molecular biology, genomics and/or bioinformatics with:

• Proven affinity for cancer and/or immunology research;
• Experience with genomic analysis from high-throughput sequencing data (R, Phython,Matlab) and affinity with statistics and machine learning will be a plus;
• The ability to work independently, but can thrive in a multi-disciplinary academic environment and communicate fluently in English, verbally and in writing.

Additional Information
Benefits

• A flying start to your career in scientific research.
• Plenty of room for personal development with a wide range of training & development of academic skills
• Working on large-scale and own research, with motivated colleagues
• A contract for 6 months with the prospect of extension for the duration.
• Salary scale: 10, 11: € 3.493tot € 5.504 bruto (based on a fulltime workweek), depending on qualifications and experience.
• Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay. Calculate your net salary here .
• Your pension is accrued at BeFrank. A modern, understandeble en fair pension
• Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces at the AMC location and a good bicycle scheme.

Additional comments

The first round of interviews is scheduled for the end of May. We ask you to take this into account in advance. The second round of interviews will take place in early June.

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
If you have any questions about this position, please feel free to contact Michiel Pegtel, Associate Professor Dept Pathology via +316 223 01 791, or via [email protected] .

For more information about the application procedure, please contact Chey Edwards, Recruitment Advisor, via +316 214 87 245 or via [email protected] .

A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Internal candidates will be given priority over external candidates in case of equal suitability.

Acquisition in response to this vacancy is not appreciated.

Website for additional job details

https://www.academictransfer.com/341079/

Work Location(s)

Number of offers available

1

Company/Institute

Amsterdam UMC

Country

Netherlands

City

Amsterdam

Postal Code

1081HV

Street

De Boelelaan 1117

Geofield

Where to apply

Website

https://www.academictransfer.com/en/341079/post-docbioinformatician-liquid-biop…

Contact

City

Amsterdam Zuidoost

Website

https://www.amsterdamumc.org/

Street

Meibergdreef 9

Postal Code

1105 AZ

STATUS: EXPIRED