Ph.D. Candidate Position on Gynaecologic Oncology – Maastricht University

18 May 2023
Job Information

Organisation/Company

Maastricht University (UM)

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

4 Jun 2023 - 21:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

38.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We are looking for highly motivated candidate willing to work on in vitro three-dimensional models and on mouse models of endometrial cancer.

Our research team has been focussing for several years on the role of steroid hormones in gynaecological diseases. In the context of endometrial cancer, we have been exploring the position of hormonal treatment for this disease, the mechanisms underlying the resistance of cancers towards these medications, and we have been engaged in novel drug discovery.

In the present project, the PhD candidate will study preclinically the efficacy of a novel hormonal drug for the treatment of endometrial cancer. The study will be conducted using two mouse models of endometrial cancer, specifically a metastatic model that was developed in our lab, and a model based on patient derived xenografts. In parallel, the candidate will use in vitro 3D organoid/spheroid models of endometrial cancer to explore therapeutic efficacy, development of resistance and the role of combinational drug regimens. These activities will be complemented with observational investigations of patient materials.

Scientific embedding
State-of-the-art technology will be available: animal facilities for housing, in vivo imaging including CT, PET-CT and bioluminescence; in vitro facilities for cell culturing; facilities for handling transgenic materials; advanced microscopy unit including electron, confocal and two photons microscopy; facilities and core units for genetic analyses (bulk, single-cell level and with spatial resolution), Mass Spectrometry and Mass Spectrometric Imaging and flow cytometry.

The research team for the daily work consists of one senior scientist, one senior analyst, one PhD candidate who will work in close collaboration with the new candidate, the PI and ad hoc appointed master and bachelor students. Further, the PhD candidate will work in cooperation with personnel from other departments for the use of advanced in vitro platforms and for ad hoc analyses. The candidate will be exposed to the multidisciplinary research environment available at our department, where clinicians from various specialties (gynaecologic oncology, benign gynaecology and fertility doctors), molecular cell biologists, bioinformaticians and data science experts and bioengineers meet and discuss regularly. Further, the PhD candidate will be exposed to the existing large international network of the research team.

Requirements
Specific Requirements

• Interest in gynaecologic oncology;
• Strong communication and teamwork skills;
• Experience with cell culture and basic molecular techniques;
• Preferably: previous experience with handling of mice;
• Mandatory: enthusias.

Additional Information
Benefits

Our offer

• We provide a multidisciplinary team of biologists, bioinformaticians and medical doctors devoted to study and find solutions for patients with gynaecologic oncologic problems or gynaecologic diseases.
• Exposure to large international networks including the European Network for Individualised Treatment of Endometrial Cancer (ENITEC).
• State-of-the-art technologies and facilities.
• Various educational trainings available at our graduate school and university.

Temporary employment (1.0 FTE) for 4 years. The first year will be a probation period, after a positive assessment the position will be extended for another 3 years, which happens in the vast majority of cases.

Your salary will be € 2,541 gross per month in the first year up to € 3,247 gross per month in the fourth year according to the PhD-candidate salary scale. An 8% holiday and an 8.3% year-end allowance is also provided.

In addition to good primary employment conditions, UM also offers an attractive package of secondary employment conditions.

Each year an evaluation will take place.

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl  > About UM > Working at UM .

Selection process

You can respond to this vacancy by sending your motivation letter and CV (as pdf file), stating the vacancy number AT2023.234, by email to:
[email protected]

Maastricht University is committed to promoting and nurturing a diverse and inclusive community. We believe that diversity in our staff and student population contributes to the quality of research and education at UM, and strive to enable this through inclusive policies and innovative projects led by teams of staff and students. We encourage you to apply for this position.

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Additional comments

For more information about this position, please contact:
Andrea Romano, T: 0031 (0)43 388520, E: [email protected]

To apply at this vacancy, press the button ‘apply now’ to see the application procedure.

Website for additional job details

https://www.academictransfer.com/327936/

Work Location(s)

Number of offers available

1

Company/Institute

Maastricht University

Country

Netherlands

City

Maastricht

Postal Code

6229 HX

Street

P. Debyelaan 25

Where to apply

Website

https://www.academictransfer.com/327936/phd-candidate-position-on-gynaecologic-…

Contact

City

Maastricht

Website

http://www.maastrichtuniversity.nl/

Street

Minderbroedersberg 4

Postal Code

6211 LK

STATUS: EXPIRED