The Neuroimmunology group, led by Prof. Michael Heneka, has started its activities at LCSB in early 2022. It focuses on the role of immune mechanisms in neurodegenerative diseases, with a particular focus on Alzheimer’s disease.
The Neuroimmunology group at the LCSB has an immediate opening for a motivated and talented laboratory technician (entry- to advanced- level position) to assist with in vivo animal experimentation using mouse models of neurodegenerative disease. In vivo imaging techniques as well as tests assessing motor, learning and memory functions will be important readouts. Additional tasks include histochemistry, immunohistochemistry, genotyping, protein and RNA extraction methods as well as related detection methods (FACS, ELISA, Western blot, qPCR).
As a general task you will support the group’s daily lab operations, including ordering lab supplies, sample organization and documentation. Experimentally, you will assess animal behavior and in particular learning and memory function using sophisticated new video-based and classical learning and memory paradigms. Additionally, you will assess the in vivo imaging of intracerebral cell activity and behavior using several imaging techniques including but not restricted to 3-photon laser scanning microscopy. Protein expression analysis by immunhistochemistry, ELISA or immunoblot detection are further tasks.
Important technical competencies and tasks include, but are not limited to:
- Experience in working with rodent models and FELASA certification
- Solid knowledge on animal behavior assessment
- Live cell imaging skills, microscopy
- Troubleshooting of technical problems in sample preparation and extraction workflows
- Experience with standard techniques of molecular biology (Immunhistochemistry, FACS, ELISA; Western blot, qPCR)
- Thorough record keeping in a well-organized lab notebook
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