In osteosarcoma, low expression or frequent mutations of single components of the DAXX/ATRX histone H3.3 chaperon/nucleosome remodeling complex lead to increased levels of RNA:DNA hybrid related genomic stability at telomere and non-telomere sites. The project aims to understand mechanisms that recruit ATRX/DAXX to sites of RNA:DNA hybrids. In a second step, therapeutic strategies that block ATRX/DAXX recruitment to RNA:DNA hybrid sites such as telomeres will be investigated. Candidates should have experience in standard methodology related to protein-protein interaction, cancer cell biology, immunofluorescence microscopy and cell culture techniques. Specialized experience in the analysis of genomic stability and chromatin structure, analysis of DNA replication, RNA biology and experience in FISH technology are an additional plus during the candidate selection process.
Master Thesis Biochemical Modification Of Conductive Protein Fibers For The Next Generation Bioelectronics, Helmholtz, Germany, 2 days ago
Your Job: The Master thesis project aims to develop a novel biochemical approaches for the manipulation of conductive cable bacteria fibers. The secret of cable bacteria conductivity is in their p...
Research Specialist In Stem Cell Biology, Karolinska Institute, Sweden, about 22 hours ago
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A*Star Research Attachment Programme (Arap), University of Warwick, United Kingdom, about 3 hours ago
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Associate Staff Scientist, University of Arkansas, United States, 6 days ago
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Senior Technician Testa Laboratory , Human Technopole Foundation ;, Italy, 11 days ago
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Lab Manager – Single Cell Epigenomics And Cancer Development Lab, Centre for Genomic Regulation, Spain, about 12 hours ago
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