The placenta during pregnancy releases a wide range of molecules into both the maternal and fetal circulation, and many of these can easily reach the central nervous system (CNS).
The aim of the project is to test the hypothesis that the placental secretome regulates the physiology of a particular type of glia: astrocytes, resident cells of the CNS of importance for the functionality and survival of neurons, but also capable of promoting inflammation and neurodegeneration. For their dual function, astrocytes are considered key cells for the health of the brain.
In vitro cultures of human placenta will be used to assess whether placental insults affect the physiology of astrocytes or whether the neurotoxic function of activated astrocytes towards an inflammatory phenotype can be mitigated by exposure to the placental secretome.
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