Investigating the role of IGLV1-44 in the pathogenesis of AL amyloidosis and POEMS

10 May 2024
Job Information

Organisation/Company

Università di Pavia

Research Field

Biological sciences

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)

Country

Italy

Application Deadline

6 Jun 2024 - 23:59 (UTC)

Type of Contract

To be defined

Job Status

Not Applicable

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The project aims to investigate the role of the immunoglobulin gene IGLV1-44 in the pathogenesis of AL amyloidosis with cardiac involvement and POEMS syndrome, by sequencing patient-specific clonal light chains of type IGLV1-44 from a large cohort of patients, performing detailed biochemical characterization, evaluating their cytotoxic effect in preclinical models of disease, and developing nanobodies with therapeutic potential. The selected candidate will be responsible for managing a biorepository of biological samples from patients, conducting immunoglobulin repertoire sequencing studies using next-generation sequencing methods, contributing to immunoinformatics analysis, setting up an innovative cellular model for studying neurotoxicity from immunoglobulin light chains, and testing the therapeutic potential of nanobodies in cellular models of immunoglobulin light chain toxicity.

Requirements
Additional Information
Eligibility criteria

The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: http://www-assegni.unipv.it/bandi-dipartimenti-tipo-b/
Main requirements are:1) degree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D.M. n. 509/1999) or post-graduate degrees (pursuant to D.M. n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent - for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment; 2) scientific or professional curriculum suitable for conducting the research activity; 3)if available, any Ph.D. title (Art 2- par. 1).

Further specific assessable qualifications (see Art. 6):
Demonstrated experience in one or more of the following areas is required:
Molecular biology studies
Next-generation sequencing
Cellular biology studies
Flow cytometry
Biochemistry studies

Knowledge of English

Eligible destination country/ies for fellows:

• Italy

Eligibility of fellows: country/ies of residence:

• AFRICA
• EUROPE
• OCEANIA
• NORTH AMERICA
• SOUTH AMERICA
• ASIA
• OTHER
• E.U.
• CHINA (MAINLAND)
• CHINA (HONG KONG)

Eligibility of fellows: nationality/ies:

• AFRICA
• EUROPE
• OCEANIA
• NORTH AMERICA
• SOUTH AMERICA
• ASIA
• OTHER
• E.U.
• CHINA (MAINLAND)
• CHINA (HONG KONG)

Selection process

The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page:https://pica.cineca.it/unipv
by choosing the “Assegni di ricerca”; item and selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carriedout on the basis of qualifications, project and interview, supplemented by a test of knowledge of the foreign language (see art. 6 - paragraph 1).The candidate selection will take place on the basis of the documented qualifications and a personal interview, completed by a test concerning the knowledge of foreign language (see Art. 6 par 1

Website for additional job details

http://www-assegni.unipv.it/bandi-dipartimenti-tipo-b/

Work Location(s)

Number of offers available

1

Company/Institute

Università di Pavia

Country

Italy

Geofield

Where to apply

Website

https://pica.cineca.it/unipv

Contact

City

Pavia

Website

https://web.unipv.it

STATUS: EXPIRED