Call fo Application n. ISOF_287_2024_BO "NO-Cancer-Net Project 5 – Novel TME responsive and targeted systems releasing NO, ROS or drugs upon external stimuli application"

17 Jan 2024
Job Information

Organisation/Company

Consiglio Nazionale delle Ricerche

Department

Istituto per la Sintesi Organica e la Fotoreattività

Research Field

Chemistry » Organic chemistry

Researcher Profile

First Stage Researcher (R1)

Country

Italy

Application Deadline

29 Feb 2024 - 16:59 (Europe/Rome)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

36

Offer Starting Date

1 Jun 2024

Is the job funded through the EU Research Framework Programme?

H2020 / Marie Skłodowska-Curie Actions

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Project Objectives: The use of light or ultrasounds to selectively induce the generation of reactive oxygen and nitrogen oxygen species such as singlet oxygen (1O2) and nitric oxide (NO) represents a fascinating and powerful mean to spatiotemporally control the release of photo- toxic species. The DR will design and develop novel molecular conjugates combining near infrared light activatable NO donors and properly selected photosensitizers to induce the concomitant formation of high local concentration of NO and ROS. In parallel, DR5 will design and develop innovative molecular conjugates made of a LNOD unit connected through a TME- responsive linker with a cytotoxic drug to assess the effect of this combination on tumour cells growth. To further enhance the treatment selectivity and with the aim of specifically relief the hypoxic condition of the tumour microenvironment, DR5 will also incorporate the conjugates into biocompatible and oxygen-donating nanoparticles.

Secondment(s): The applicant will undertake three secondments including secondment 1 at Innovamol Consulting, for performing data analysis and molecular modelling (approx. 1 month); secondment 2 at the University of Udine under the supervision of Professor Rapozzi, for performing in vitro assays on novel conjugates (approx. 3 months), and secondment 3 at the University of Galway under the supervision of Professor Glynn for performing in vitro assays on 3D cells cultures models (approx. 3 months).The applicant will undertake three secondments including secondment 1 at Innovamol Consulting, for performing data analysis and molecular modelling (approx. 1 month); secondment 2 at the University of Udine under the supervision of Professor Rapozzi, for performing in vitro assays on novel
conjugates (approx. 3 months), and secondment 3 at the University of Galway under the supervision of Professor Glynn for performing in vitro assays on 3D cells cultures models (approx. 3 months).

Requirements

Research Field

Chemistry » Other

Education Level

Master Degree or equivalent

Skills/Qualifications

Excellent communication, organisational and interpersonal skills
Excellent report writing, presentations and IT skills.
Flexibility and ability to work in a team environment.
Hands-on experimental and analytical skills
Excellent skills in data interpretation

Specific Requirements

Master in chemistry/industrial chemistry (organic)/Pharmaceutical Chemistry/Medicinal Chemistry;

 

Languages

ENGLISH

Level

Excellent

Additional Information
Benefits

Marie Sklodowska-Curie Doctoral Candidates are paid a competitive gross salary of 3,400 €/month, adjusted for their host country, a Mobility Allowance of 600 €/month and, for researchers who have a family, a Family
Allowance of 660 €/month. All amounts are subject to deductions and taxes. Family is defined as persons linked to the researcher by (i) marriage, or (ii) a relationship with equivalent status to a marriage recognised by the national legislation of the country of the beneficiary or of nationality of the researcher, or (iii) dependent children maintained by the researcher. Should the fellow’s personal status (marriage, children) change during the action, they will also become eligible for family allowance.

Eligibility criteria

Have — at the date of recruitment — a Bachelors and/or Master’s degree in a discipline as indicated in the project description specific to the beneficiary to which you are applying;
Trans-national mobility: The applicant — at the date of recruitment — should not have resided in the country where the research training takes place for more than 12 months in the 3 years immediately prior to recruitment, and not have carried out their main activity (work, studies, etc.) in that country. For refugees under the Geneva Convention (1951 Refugee Convention and the 1967 Protocol), the refugee procedure (i.e. before refugee status is conferred) will not be counted as ‘period of residence/activity in the country of the beneficiary’;
Be able to communicate fluently in English (speaking and writing). Oral interview with the prospective advisor may be required.

Selection process

CV evaluation and oral interview

Website for additional job details

https://www.isof.cnr.it/jobs/

Work Location(s)

Number of offers available

1

Company/Institute

Consiglio Nazionale delle Ricerche (CNR) - Istituto per la Sintesi Organica e la Fotoreattività (ISOF)

Country

Italy

State/Province

Bologna

City

Bologna

Postal Code

40129

Street

Via P. Gobetti, 101

Geofield

Where to apply

E-mail

[email protected]

Website

https://forms.gle/x2qQrv1p7Bb7PKWU6

Contact

City

BOLOGNA

Website

http://www.isof.cnr.it

Street

Via Piero Gobetti 101

E-Mail

[email protected]

Phone

0516399845

STATUS: EXPIRED