A Ph.D. position in Chemistry at the University of Iceland is open for applications. The scholarship is funded by a three-year PhD scholarship from the Research Fund of the University of Iceland. We are looking for an enthusiastic PhD student to synthesize stable radicals and conjugate them to biopolymers, in particular peptides and nucleic acids.
The project: Biradicals for DNP NMR of biopolymers inside and outside cells
Stable organic radicals have numerous applications, ranging from polymer chemistry to spectroscopic studies. We have extensive experience in our laboratory in the synthesis of radicals as reporter groups for electron paramagnetic resonance (EPR) spectroscopy and incorporation of such labels into specific positions of DNA and RNA. More recently, we have been working on preparation of biradicals for increasing the sensitivity of NMR spectroscopy through the new and exciting field of Dynamic Nuclear Polarization (DNP). The aim of this project is to synthesize new radicals and to conjugate them to peptides and oligonucleotides for directed delivery into cells, for DNP NMR investigation of biopolymers and metabolites í specific organelles. These studies will be carried out in collaboration with scientists at the Karolinska Institute, Sweden, and ETH, Switzerland.
The research group
Supervisor is Prof. Snorri Th. Sigurdsson, Department of Chemistry, School of Engineering and Natural Sciences (https://scholar.google.com.br/citations?user=Ao9HoBUAAAAJ&hl=en ). Our research group is located at the Science Institute of the University of Iceland. Information about The Sigurdsson Group can be found at our website (https://notendur.hi.is/~snorrisi/ ) and the details of our research activities in our list of publications.
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