Senior Scientist in ONE Microscopy (f/m/d)

The position is funded through an ERC Synergy grant (Ultraresolution), with the aim to develop and implement fluorescence imaging approaches with a resolution below 1 nm, able to analyze protein structures using light.

About us:

Neurons contain hundreds of specialized proteins, whose topology reflects activity, plasticity and disease. Present imaging techniques are unable to present this topology accurately, since even the best super-resolution tools are limited to at least 20-30 nm, many times the size of individual proteins (~3-7 nm). To solve this problem, our ground-breaking objective is to develop reliable ultra-resolution imaging, with true molecular resolution of 1 nm or below. The solution to this problem has been recently obtained, in the form of one-step nanoscale expansion (ONE) microscopy, in which we combine the 10-fold axial expansion of the specimen (1000-fold by volume) with a fluorescence fluctuation analysis to enable the description of cultured cells, tissues, viral particles, molecular complexes and single proteins. We now plan to develop and enhance ONE microscopy, to enable it to describe protein structures in health and disease. Our lab is part of an excellent, international collaboration team, including groups on several continents, offering a dynamic and stimulating working environment.

Your tasks:

• Developing ONE microscopy approaches for different types of samples, from purified proteins in vitroto tissues
• Innovating in the expansion microscopy field, in the direction of multi-protein detection and label-free detection
• Supervising PhD students, MSc students, technical assistants and post-doctoral fellows within the ONE microscopy team of the Institute
• Writing manuscripts on ONE microscopy and grant applications for further financial support for this technology
  

Your profile:

• You must be an experienced and motivated researcher, interested in developing and leading a scientific project
• You must have a doctoral degree in physiology, biochemistry or a related subject
• Demonstrated ability to supervise and lead scientific personnel is desirable
• Strong experience with expansion microscopy approaches is required
• Strong experience with fluorescence fluctuation approaches is required
• Experience with ONE microscopy is strongly desired
• You are able to work independently and also in a team
• A good command of the English language is required
  

Our Offer:

• Working in a highly motivated, international, young and skilled team
• An interdisciplinary, innovative, and well-equipped scientific environment
• Salary according to the collective agreement for the public State service (TV-L) including social benefits 

Please send the PDF file of your application including your CV, brief motivation letter and the names of three academic referees by e-mail to [email protected]. Only applicants selected for interview will be contacted after the application deadline.

The University Medical Center Göttingen is committed to professional equality. We therefore seek to increase the proportion of under-represented genders. Applicants with disabilities and equal qualifications will be given preferential treatment.

Please send your application only via e-mail as a PDF-file.

Travel and application fees cannot be refunded or transferred.