Postdoc / Staff Scientist (f/m/x) in Computer-aided, Structure-based Drug Discovery

At our institute you will find a scientifically stimulating inter­national environment. Together with renowned scientists and suppor­ted by an excellent infra­structure you will have the opportunity to make an important contri­bution for a healthier society.

Primary research activity of the Structure-based Drug Discovery Group is to identify new potential drugs with focus on protein-protein inter­action and new tar­gets scouting. Protein-protein inter­actome usually require compounds of unique chemical proper­ties seldom found in con­temporary screening libraries. We are developing AI tools to identify new chemical sub­stances and test them in biological systems. With the help of AI, fragment-based screening, NMR-based SAR evaluation, and X-ray crystallo­graphy, we design molecules that can serve as a chemical probe to vali­date novel therapeutic proof of concept and can be optimized into future drug candidates.

We are working within the Institute of Structural Biology  at the Helmholtz Zentrum München. It focuses on integra­tive structural biology and struc­ture-based drug discovery, combining structural biology, NMR (nuclear magnetic resonance), crystallography, cryo-EM, computa­tional approaches, and chemical synthesis to develop and apply novel approaches beyond current state-of-the-art for the discovery of new tar­gets and therapeutic small molecules. Therapeutic targets address a range of topics, ranging from diabetes, cancer, lung disease to targets in para­sitic diseases and anti­biotic resistance.