Group Leader as Platform Leader (m/f/d)

Group Leader as Platform Leader (m/f/d)
Genome editing in preclinical disease models
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wanted at the next possible time at Department of General Pharmacology.

The genome editing platform will be established within the Department of General Pharmacology (Prof. Dr. Marc Freichel) and in the context of the Health + Life Science Alliance Heidelberg Mannheim (https://www.health-life-sciences.de ). The group will have resources for the position of the leader, consumables and technical support. Support will also be provided for acquiring additional third-party funding. The platform will have close connections to existing core facilities and platforms of the Health + Life Science Alliance and its seven institutions, as well as research consortia such as the German Health Centers (DZHK, DKTK, DZL, DZIF) and Collaborative Research Centers (CRCs) at Heidelberg University. Collaboration with these institutions and research consortia is explicitly desired. Additionally, an interest in participating in new collaborative initiatives, including new clusters of excellence, is expected.

The research and tasks of the platform include:
• Development and optimization of genome editing procedures: The group works on developing new technologies and methods for precise genome editing and further advancing existing procedures. This includes techniques such as CRISPR/Cas9, Base Editing, and Prime Editing.
• Establishment of preclinical disease models: By applying genome editing techniques, preclinical disease models are developed in mice and other animal or organoid models. These models allow for investigating the molecular basis of diseases, identifying signaling pathways, and exploring new therapeutic approaches.
• Development of in vitro models: The Junior Research Group also utilizes in vitro models derived from iPS cells. These cell models enable the investigation of disease mechanisms in a controlled environment and the testing of potential therapeutic approaches.

• Job-ID: V000012399
• Field of application: Pharmakologisches Institut
• Location: Heidelberg
• Start date: as of now
• Job Category: Science and teaching
• Working hours: full-time
• Published: 11.03.2024
• Limitation:Temporary (31.12.2027)
• Contract:TV-L

Your Tasks

• You are responsible for further development of technologies in the field of genome engineering
• You will help establish and lead the platform as an information, contact, and service facility for members of the Health + Life Science Alliance
• In your role as the platform leader, you will be responsible for finances and personnel
• In close coordination with the Department of General Pharmacology and in collaboration with Health + Life Science Alliance management your role will involve spearheading the further development of the platform
• You will actively be involved in research questions related to genome editing within the Health + Life Science Alliance Heidelberg Mannheim.
• You will establish collaborative projects with other members of the Health + Life Science Alliance within the framework of funding instruments for research consortia (DZGs, CRCs) at Heidelberg University
• Your expertise will be integrated into future project proposals to acquire further funding for the implementation of genome engineering techniques
• Optionally, you may participate in university self-administration and teaching

Your Profile

• A successfully completed Ph.D. in biosciences, medicine, veterinary medicine, pharmacy, or an equivalent degree is required
• Solid knowledge and extensive experience in the generation and molecular analysis of transgenic model systems in animals, especially in mice, or in iPS cells with the application of genome editing techniques are essential
• Good English language skills and German language skills are desirable
• You demonstrate the ability to work independently and autonomously
• Evidence of leadership experience and experience in supervising final theses is advantageous and will be positively evaluated
• Enthusiasm for an exciting, dynamic, and challenging position in medically oriented

We offer

• Collectively agreed remuneration, attractive company pension scheme (VBL)
• 30 days vacation
• Sustainable travel: job ticket
• Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
• Wide range of health, prevention and sports offers
• Close collaboration and support in administrative tasks with the Department of General Pharmacology (Head Prof. Dr. Marc Freichel) and other research groups within the Health + Life Science Alliance interested in genome editing techniques
• A diverse field of activity at the interface of medicine, biology and bioinformatics
• The opportunity to be closely involved in the activities and networks of Heidelberg University and the Health + Life Science Alliance
• In addition you will benefit from the extensive research network of the involved workgroups and collaboration partners
• Modern facilities and laboratory equipment at the Pharmacological Institute
• Regular training and further education opportunities to promote your personal and professional career
• Flexibility in work arrangements, including the possibility to work partly from home
• A competitive salary commensurate with your qualifications, based on salary group E14/E15 within the TV-L framework
• Company pension scheme for your long-term financial security
• The attractive university cities of Heidelberg and Mannheim in Baden-Württemberg offer a high quality of life and diverse educational opportunities

Contact & Application

For inquiries, please contact Prof. Dr. Marc Freichel via email or phone: +49 6221-54 86860.

Interested? 

Please submit your application, including the usual documents, via email by March 31st, 2024 to: [email protected]  

Pharmakologisches Institut
Prof. Dr. Marc Freichel
Im Neuenheimer Feld 366
69120 Heidelberg
Tel.: 06221 54 86860
[email protected]

Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.

The UKHD embraces diversity and values diversity.

Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.