7 Mar 2024
Job Information
- Organisation/Company
Helmholtz-Zentrum für Infektionsforschung- Research Field
Medical sciences- Researcher Profile
First Stage Researcher (R1)- Country
Germany- Application Deadline
23 Mar 2024 - 23:00 (UTC)- Type of Contract
To be defined- Job Status
Other- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Area of research:
Promotion
Part-Time Suitability:
The position is suitable for part-time employment.
Job description:Area of research:
The Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) focusses on identifying and developing new treatment options for infectious diseases with an emphasis on natural product research. HIPS was jointly started in August 2009 by the HZI in Braunschweig and Saarland University on Campus Saarbrücken.
In 2015 HIPS moved into a new 4500 m2 research building in which currently 220 international employees work. HIPS represents the first and only publicly funded extra-university research unit in Germany dedicated to pharmaceutical research. The Institute collaborates with universities and various industries both nationally and internationally. Researchers in the department Anti-infectives from Microbiota are analyzing and identifying novel natural products from unique bacterial speciesand microbial consortia applying diverse approaches and methods mainly from the field of biotechnology, microbiology, molecular biology and biochemistry.
The PhD project META-NAT focusses on the identification of novel bacterial natural product producers and the metabolic analysis of communities thereof. The project will make use of state-of-the art microbiological techniques and sequencing technologies, and combine bacterial cultivation with natural product discovery efforts to understand the natural functions of secondary metabolite.
The PhD project is structured in three interconnected research pillars:
1. Isolation and genome sequencing of (marine) bacterial symbionts
- Isolation and cultivation of bacterial strains
- Testing of different microbial (co-)cultivation techniques
- Isolation of DNA and whole genome sequencing
2. Metabolic analysis of (marine) wild-type natural product producers
- Focus on the secondary metabolome of bacterial producers
- In collaboration, isolation of novel natural products
- Utilizing high-resolution mass spectrometry to monitor and optimize product formation
3. Design and analysis of bacterial co-cultures
- Design and metabolic analysis of multitrophic bacterial co-cultures.
- Optimizing cultivation conditions of bacterial co-cultures
- If possible, establish RNA-sequencing protocols of bacterial co-cultures
In this project, the successful candidate will contribute to cultivating novel bacterial species and spearhead genome-sequencing efforts for genome mining and comparative studies. Analysis of fermentation conditions and co-cultures will ignite studies into the natural product repertoire. A particular focus should be set on multi-trophic co-culture settings. The PhD candidate will have the chance to be trained on state-of-the-art analytical instruments and use this knowledge for natural product identification efforts. This multi-faceted approach will enable the candidate to gain expertise in microbial cultivation techniques and apply advanced molecular biological and analytical tools for the identification of novel natural products. This multi-faceted approach will enable the candidate to gain expertise in microbial cultivation techniques as well as advanced molecular biological and analytical tools for the identification of novel natural products.
We offer:
- Modern laboratories and state-of-the-art instrumentation, a dynamic and international research environment
- Extensive further training opportunities and the opportunity to enroll in a structured PhD program
- Unique network of excellent partners to support your research endeavors
- 30 days vacation (24.12. & 31.12. are considered as completely free days)
- An annual additional payment (Weihnachtsgeld) analogue to § 20 TVöD
- Social security included
- Flexible working hours
- A corporate culture of appreciation and promotion of equal opportunities
- Support for a better balance between work and private life through our family office
Prerequisite:
Qualifications:
- Master degree or equivalent in Life Sciences, Biotechnology, Pharmacy Chemistry, or related fields.
- Strong hands on experience in laboratory and in particular microbiological cultivation techniques.
- General understanding of molecular biological approaches, sequencing technologies, chemical and biochemical transformations
- Ability to pay attention to details, pursue research independently and work in a goal-oriented manner.
- Willingness to work in a plural, collegial, international and interdisciplinary environment.
- Excellent English communication skills (written and spoken); very good skills in scientific writing
Advantageous for this position:
- Experience in next-generation sequence methods/techniques
- Experience in DNA isolation, PCR and cloning techniques
- Isolation of bacterial strains, microbial cultivation techniques, phylogenomic analyses
Disabled persons are given preference in the case of equal professional qualification. The HIPS aims for professional equality between women and men. The position is suitable for part-time work.
Salary:alike TVöD (Bund) E13 (65%)
This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany's largest scientific organisation.
Requirements
Additional Information
- Website for additional job details
https://www.helmholtz-hzi.de/en/career/jobs/open-positions/jobs/view/job/detail…
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Helmholtz-Zentrum für Infektionsforschung
- Country
- Germany
- City
- Saarbrücken
- Geofield
Where to apply
[email protected]- Website
https://www.helmholtz-hzi.de/en/career/jobs/open-positions/jobs/view/job/detail…
Contact
- City
Braunschweig- Website
http://www.helmholtz-hzi.de- Street
Inhoffenstraße 7- Postal Code
38124
[email protected]- Phone
+49 531 6181-0- Fax
+49 531 6181-2655
STATUS: EXPIRED