1 Early-Stage Researcher position inMarie Sklodowska Curie ITN“Nanoparticle-based imaging andtherapy of chronic pain in the dorsalroot ganglia”(PIANO)

29 Aug 2023
Job Information

Organisation/Company

medres

Department

R&D

Research Field

Physics » Biophysics

Researcher Profile

First Stage Researcher (R1)

Country

Germany

Application Deadline

30 Sep 2023 - 23:59 (Europe/Berlin)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

36

Offer Starting Date

1 Sep 2023

Is the job funded through the EU Research Framework Programme?

H2020 / Marie Skłodowska-Curie Actions

Reference Number

H2020-MSCA-ITN-PIANO

Marie Curie Grant Agreement Number

956477

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

One "Early Stage Researcher" position is available within the EU-funded Marie Skłodowska Curie Innovative Training Network on
NANOPARTICLE-BASED IMAGING AND THERAPY OF CHRONIC PAIN IN THE DORSALROOT GANGLIA (PIANO - GA 956477)

PIANO Project Description:
Chronic pain is a debilitating disease that affects approximately 1.5 billion people worldwide,and of those approximately 4% suffer from neuropathic pain. Neuropathic pain is often theresult of nerve damage or a malfunctioning nervous system. It is described as a shooting orburning sensation that can come and then disappear, but it may also become chronic suchthat the pain becomes unrelenting and severe. Of equal note is the impact of chronic painupon society as the costs related to disability allowance, treatment, lost wages and productivity impact the economy. Since current treatments for chronic pain are not entirely reliable, a betterunderstanding of the mechanisms underlying chronic pain will provide new targets foranalgesia.
The PIANO Network aims to develop tools to identify and visualise mechanisms of nociceptionin the dorsal root ganglia (DRG), outside the central nervous system (CNS). The DRG containthe cell bodies of specialised neurones that detect harmful stimuli in the periphery of the bodyand transmit noxious signalling to the spinal cord in the CNS.
We propose that local and targeted interventions at the level of the DRG will provide anopportunity to circumvent CNS-related side effects and optimise analgesic therapy. In modelsof neuropathic pain, we aim to identify the DRG involved in noxious signalling by visualisingcells or molecules in the DRG which are directly or indirectly associated with the transmissionof pain.
We will use novel methodologies based on nanoparticles targeted delivery to pain-related cellsand molecules in the DRG. A good number of studies have shown a significant infiltration ofmacrophages into relevant DRG under neuropathic pain conditions. PIANO’s nanoparticles willbe specifically designed to target the macrophages in the DRG, encapsulating boththerapeutic payloads and imaging contrast reagents to monitor pain-driven activities.

Here is a link to the rpojects' website:

PIANO, a H2020 MSCA ITN project (pianoitnmsca.com)

 

INDIVIDUAL ESR PROJECT: Instrumentation and monopolar and bipolar probes/electrodes for neurophysiological monitoring

JOB OFFERS DETAILS: A structured cutting-edge training programme is provided: in and beyond the fields ofneuropathic pain and its biological basis, biomaterials, chemistry, nanoparticles andimaging. In addition to the individual training-through-research, the programme includes further elements such as workshops, summer schools, internships andsecondments to the partners’ laboratories. The position is available until the actual project-end that is: 28.02.2024, starting from 01. September 2023.

BENEFITS: The successful candidate will be funded with a competitive salary in accordancewith the MSCA regulation for Early Stage Researchers, including living allowance, mobilityallowance and a family allowance (if applicable).

ELIGIBILITY CRITERIA: The following eligibility rules apply for participation in a Marie Skłodowska Curie InnovativeTraining Network: Applicants must be in the first 4 years after obtaining their Master´s degree Applicants must not have resided or carried out their main activity (work,studies, etc.) in Germany for more than 12 months in the 3 yearsimmediately before the recruitment date.

APPLICATION PROCESS: To apply for the position please send the following information to: Lynda Zeboudj <lynda.zeboudj@kcl.ac.uk >

- your complete CV,
- motivation letter,
- copies of University Master certifi cates or equivalents
- contact details of two referees, who can provide a letter of recommendation.

Please state the vacancy reference "PIANO ESR application" in the subject line. After eligibility screening, your application will be forwarded to the Selection Committee forfurther evaluation. Shortlisted candidates will be invited for interviews.

NEEDED SKILLS: We are looking for highly motivated and talented candidate holding a Master's degree inscientific fields like biology, chemistry, biochemistry or neuroscience. Excellent command ofspoken and written English, communication skills as well as team spirit are essential.

 

Requirements

Research Field

Physics » Biophysics

Education Level

Master Degree or equivalent

Skills/Qualifications

We are looking for highly motivated and talented candidate holding a Master's degree inscientific fields like biology, chemistry, biochemistry or neuroscience. Excellent command ofspoken and written English, communication skills as well as team spirit are essential.

Languages

ENGLISH

Level

Excellent

Additional Information
Benefits

The successful candidate will be funded with a competitive salary in accordancewith the MSCA regulation for Early Stage Researchers, including living allowance, mobilityallowance and a family allowance (if applicable).

Eligibility criteria

The following eligibility rules apply for participation in a Marie Skłodowska Curie InnovativeTraining Network: Applicants must be in the first 4 years after obtaining their Master´s degree Applicants must not have resided or carried out their main activity (work,studies, etc.) in Germany for more than 12 months in the 3 yearsimmediately before the recruitment date.

Selection process

To apply for the position please send the following information to: Lynda Zeboudj <lynda.zeboudj@kcl.ac.uk >

- your complete CV,
- motivation letter,
- copies of University Master certifi cates or equivalents
- contact details of two referees, who can provide a letter of recommendation.

Website for additional job details

https://pianoitnmsca.com/

Work Location(s)

Number of offers available

1

Company/Institute

medres - medical research GmbH

Country

Germany

State/Province

NRW

City

Cologne

Postal Code

50931

Street

Gleueler Str. 50

Where to apply

E-mail

lynda.zeboudj@kcl.ac.uk

Contact

State/Province

NRW

City

Cologne

Website

https://www.medres.de/

Street

Gleueler Str. 50

Postal Code

50931

E-Mail

johannes.wecker@medres.de

Phone

0221-67784948

STATUS: EXPIRED